Studi Scientifici sui benefici dell’ossigeno attraverso ossigeno-ozonoterapia

L’ossigeno-ozonoterapia è oggetto di crescente interesse scientifico per i suoi potenziali effetti biologici e terapeutici. Negli ultimi anni sono stati pubblicati numerosi studi clinici e sperimentali che ne analizzano l’efficacia come trattamento di supporto in diverse patologie. Di seguito riportiamo una selezione di studi scientifici, revisioni e trial controllati, suddivisi per area clinica. Le fonti citate provengono da riviste peer-reviewed e database scientifici internazionali.

Fibromialgia

EurRev Med PharmacolSci. 2019 Feb;23(4):1786-1788. Ozone therapy in 65 patients with fibromyalgia: an effective therapy U Tirelli 1, C Cirrito, M Pavanello, C Piasentin, A Lleshi, R Taibi
https://pubmed.ncbi.nlm.nih.gov/30840304/

Rheumatol Int. 2025 Mar 12;45(4):72. doi: 10.1007/s00296-025-05827-1 Short- and Medium-Term effects of major Ozone therapy on disease parameters in fibromyalgia syndrome: A retrospective study. Ahmet Üşen, Didem Sezgin Özcan, Mehmet Ağirman, Hilal Güner, Burhan Fatih Kocyigit https://pmc.ncbi.nlm.nih.gov/articles/PMC11903636/

Dimou T. 2024. Autoemoterapia con ozono in 20 pazienti FM. Reg Anesth Pain Med (abstract).
https://rapm.bmj.com/content/49/Suppl_1/A411.2?utm_source=chatgpt.com

Sucuoğlu H. 2023. Efficacy of ozone therapy as an add-on treatment in fibromyalgia: A randomized double-blind placebo-controlled study. Hamza Sucuoğlu, Nalan Soydaş
https://journals.sagepub.com/doi/10.3233/BMR-210368

Neurodegenerative

Sclerosi Multipla

Eur J Pharmacol. 2017 Sep 15:811:148-154. doi: 10.1016/j.ejphar.2017.06.017. Epub 2017 Jun 13. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patientsLivan Delgado-Roche , Mario Riera-Romo, Fernando Mesta, Yanet Hernández-Matos 4, Juan M Barrios 5, Gregorio Martínez-Sánchez , Said M Al-Dalaien https://pubmed.ncbi.nlm.nih.gov/28623000/

Ictus Ischemico Acuto

Front Med (Lausanne). 2025 Jul 25;12:1595568. doi: 10.3389/fmed.2025.1595568 A clinical study on ozone autohemotherapy for the treatment of acute ischemic stroke Heyun Cheng 1, Rui Lu 1, Juan Du 1, Xingjuan Zhao 1, Zhijiang Zhuang 1,* https://pmc.ncbi.nlm.nih.gov/articles/PMC12331603/

Sistema cardiocircolatorio

Cardiovascular pharmacology Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease. Martínez-Sánchez, Livan Delgado-Roche, Arquímides Díaz-Batista, Gema Pérez-Davison, Lamberto Re https://www.sciencedirect.com/science/article/abs/pii/S001429991200581X

Critical Care volume 3, Article number: P121 (2000)
Oxygen-ozone treatment improves p50 std value in patients with peripheral vascular disease. R Giunta, C Luongo, C Vicario, A Sammartino, MA Marfella, G Esposito, A Coppola, B Lettieri & L Coppola. https://ccforum.biomedcentral.com/articles/10.1186/cc495

Int J ArtifOrgans Volume 28, Issue 10Extracorporeal Blood Oxygenation and Ozonation (EBOO): A Controlled Trial in Patients with Peripheral Artery Disease N.Di Paolo,V.Bocci, E.Gaggiotti https://journals.sagepub.com/doi/10.1177/039139880502801012

Ther Clin Risk Manag. 2020 Jun 29;16:579–594. doi: 10.2147/TCRM.S255247 Oxygen-Ozone (O2-O3) Therapy in Peripheral Arterial Disease (PAD): A Review Study Hanna Juchniewicz, Anna Lubkowska https://pmc.ncbi.nlm.nih.gov/articles/PMC7334138/

Sistema polmonare

Arch Med Res. 2005 Sep-Oct;36(5):549-54. doi: 10.1016/j.arcmed.2005.04.021. Ozone therapy effects on biomarkers and lung function in asthma. Frank A Hernández Rosales, José L Calunga Fernández, José Turrent Figueras, Silvia Menéndez Cepero, Adonis Montenegro Perdomo https://pubmed.ncbi.nlm.nih.gov/16099337/

Rev Med Chil. 2011 Apr;139(4):439-47. Epub 2011 Aug 25. [Rectal ozone therapy for patients with pulmonary emphysema] José Luis Calunga 1, Yuleidys Paz, Silvia Menéndez, Alfredo Martínez, Aparicio Hernández https://pubmed.ncbi.nlm.nih.gov/21879181/

American Journal of Clinical and Experimental Medicine (Volume 2, Issue 2) Oxygen Ozone Therapy in the Treatment of Chronic Obstructive Pulmonary Disease: An Integrative Approach. Emma Borrelli, Velio Bocci. https://www.sciencepublishinggroup.com/article/10.11648/j.ajcem.20140202.11

Disease and Health Research: New Insights Vol. 3 / The Use of Ozone in the Pulmonary Obstructive Disease Emma Borrelli https://stm.bookpi.org/DHRNI-V3/article/view/15445

International Immunopharmacology Volume 139, 30 September 2024, 112673 A pilot randomized controlled trial of major ozone autohemotherapy for patients with post-acute sequelae of COVID-19 Yang He, Xu Liu, Shiqian Zha, Yixuan Wang, Jingyi Zhang, Qingfeng Zhang, Ke Hu https://www.sciencedirect.com/science/article/abs/pii/S1567576924011949

Ferite /Ustioni/ Ulcere (incluso piede diabetico e venose)

J Pers Med. 2023 Sep 27;13(10):1439. doi: 10.3390/jpm13101439 Use of Ozone Therapy in Diabetic Foot Ulcers Álvaro Astasio-Picado, Alba Ángel Babiano, Miriam López-Sánchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gómez-Martín. https://pmc.ncbi.nlm.nih.gov/articles/PMC10608575

Front Endocrinol (PMC).Evaluation of the healing potential of short-term ozone therapy for the treatment of diabetic foot ulcers Haojie Sun, Hao Heng, Xuekui LiuX, Houfa Geng, Jun Liang https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1304034/

Indian J Dermatol. 2022 luglio-agosto;67(4):479. doi: 10.4103/ijd.ijd_152_22 Efficacia e sicurezza dell’ozonoterapia per i disturbi dermatologici: una revisione della letteratura sugli studi clinici Andressa Urbano Machado, Renata Vidor Contri https://pmc.ncbi.nlm.nih.gov/articles/PMC9792021/

Journal of Burn Care & Research, Volume 42, Issue Supplement_1, April 2021, Page S193, Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study. Emre Karakaya, MD, Aydincan Akdur, MD, H Ebru, Ayvazoglu Soy, MD, Alev Ok Atilgan, MD, Eda Ozturan Ozer, MD, Mehmet Haberal, MD, FACS (Hon), FICS (Hon), FASA (Hon), FIMSA (Hon), Hon FRCS (Glasg) https://doi.org/10.1093/jbcr/irab032.319

Patologie Gatroinstestinali

PMID: 17201222 [Ozone therapy in gastroduodenal pathology associated with Helicobacter pylori] A A Fedorov, A S Gromov, S V Sapronenok, V Iu Kurochkin, Z M Zhernakova https://pubmed.ncbi.nlm.nih.gov/17201222/

DOI: 10.4081/ozone.2017.7304 The use of ozonated water and rectal insufflation in patients with intestinal dysbiosis Fortunato Loprete, Francesco Vaiano https://pubmed.ncbi.nlm.nih.gov/17201222/

J Pediatr Surg. 2008 Sep;43(9):1679-84. doi: 10.1016/j.jpedsurg.2008.01.064. The efficacy of ozone therapy in experimental caustic esophageal burn Ahmet Guven 1, Gokhan Gundogdu, Serdar Sadir, Turgut Topal, Esra Erdogan, Ahmet Korkmaz, Ilhami Surer, Haluk Ozturk. https://pubmed.ncbi.nlm.nih.gov/18779006/

Patologie Epatiche

Publication: The Journal of Alternative and Complementary Medicine Preliminary Results of Ozone Therapy as a Possible Treatment for Patients with Chronic Hepatitis C Saad Zaky, Sherif Ebrahiem Kamel, Magda Shahata Hassan, Nadia Abdel Sallam, Mohamad Ahmad Shahata, Shaaban Redwan Helal, and Heba MahmoudAuthors Info & Affiliations https://doi.org/10.1089/acm.2010.0016

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Dec;22(6):484-5. [Clinilal study of medical ozone therapy in chronic hepatitis B of 20 patients] Xiu-juan Jiao 1, Xun Peng https://pubmed.ncbi.nlm.nih.gov/19544653/

Patologie Renali

Int J Artif Organi.Gennaio 2004;27(1):29-34. doi: 10.1177/039139880402700107. Efficacia clinica dell’autoemoterapia ozonizzata nei pazienti emodializzati con claudicatio intermittens: uno studio controllato con ossigeno. B Biedunkiewicz 1, L Tylicki , T. Nieweglowski , S Burakowski , B Rutkowski https://pubmed.ncbi.nlm.nih.gov/14984181/

Studio clinico randomizzato controllato Chin Med J (inglese). Settembre 2010;123(18):2510-3. Effetto dell’ozonoterapia medica sul flusso sanguigno renale e sulla funzione renale dei pazienti con epatite cronica grave Xi-bing Gu 1, Xiaojuan Yang , Hong Ying Zhu , Yue-qin Xu , Xia-ying Liu https://pubmed.ncbi.nlm.nih.gov/21034619/

Patologie Ormonali

Diabetology & Metabolic Syndrome volume 15, Article number: 140 (2023) Efficacy of ozone therapy on visual evoked potentials in diabetic patients
Morteza Izadi, Mohammad Javanbakht, Ali Sarafzadeh, Behzad Einollahi, Farzaneh Futuhi, Zahra Vahedi, Shi Zhao, Nematollah Jonaidi-Jafari, Mahboobeh Sadat Hosseini, Javad Hosseini Nejad, Effat Naeimi, Seyed Hassan Saadat, Hadi Esmaeili Gouvarchin Ghaleh, Mozhgan Fazel, Zahra Einollahi & Luca Cegolon https://pubmed.ncbi.nlm.nih.gov/37365632/

Iperplasia Prostatica

Urol Ann. Gennaio-Marzo 2017;9(1):37–40. doi: 10.4103/0974-7796.198843 Terapia intraprostatica con ozono: un approccio mininvasivo nell’iperplasia prostatica benigna Shabbir Hussain 1, , Deepti B Sharma 1 , Fanindra S Solanki 1 , Ajay Pathak 1 , Dhananjay Sharma 1. PMCID: PMC5308035 PMID: 28216927 https://pmc.ncbi.nlm.nih.gov/articles/PMC5308035/

Preliminary data were presented at the 29th European Society for Therapeutic Radiology and Oncology Annual Congress, Barcelona, Spain, September 12–16, 2010.
Long-Term Control of Refractory Hemorrhagic Radiation Proctitis With Ozone Therapy
Bernardino Clavo, Daniel Ceballos, Dominga Gutierrez, Gloria Rovira, Gerardo Suarez, Laura Lopez, Beatriz Pinar, Auxiliadora Cabezon, Victoria Morales, Elena Oliva, Dolores Fiuza, Norberto Santana-Rodriguez https://www.sciencedirect.com/science/article/pii/S0885392412004022

Oncologia e chemioterapia

Tirelli Clinical Group-Unit of Oncology, Pordenone, Italy. [email protected] Oxygen-ozone autohemotherapy in breast cancer patients suffering from fatigue and musculoskeletal pain upon aromatase inhibitors treatment: a case-series study U. Tirelli, L. Valdenassi, M. Franzini, S. Pandolfi, R. Fisichella, S. Chirumbolo https://pubmed.ncbi.nlm.nih.gov/30536352/

Physiol., 30 August 2022 Sec. Redox Physiology Volume 13 Long-term improvement by ozone treatment in chronic pain secondary to chemotherapy-induced peripheral neuropathy: A preliminary report Bernardino Clavo, Delvys, Saray Galván, Mario Federico, Gregorio Martínez-Sánchez, Yolanda Ramallo-Fariña, Carla Antonelli, Gretel Benítez, Dolores Rey-Baltar, Ignacio J Jorge, Francisco, Rodríguez-Esparragón, Pedro Serrano-Aguilar. https://doi.org/10.3389/fphys.2022.935269

BJR Case Rep. 2023 Jun 13;9(4):20220078. doi: 10.1259/bjrcr.20220078
Medical ozone on hamstring injury in a professional athlete assessed by thermography: a clinical case report Francisco Javier Hidalgo-Tallón, Rosa Pinto-Bonilla, Jose Baeza-Noci, Silvia Menéndez-Cepero, Alessio Cabizosu https://pmc.ncbi.nlm.nih.gov/articles/PMC10412915

STUDI SCIENTIFICI SUL SELENIO

JAMA 276 (1996): 1957–1963
Effect of Selenium Supplementation for Cancer Prevention in Patients with Carcinoma of the Skin: The Nutritional Prevention of Cancer Trial
Clark LC, Combs GF Jr, Turnbull BW, et al.
https://pubmed.ncbi.nlm.nih.gov/8971064/

JAMA 301 (2009): 39–51
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Lippman SM, Klein EA, Goodman PJ, et al.
https://pubmed.ncbi.nlm.nih.gov/19066370/

JAMA 306 (2011): 1549–1556
Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Klein EA, Thompson IM Jr, Tangen CM, et al.
https://pubmed.ncbi.nlm.nih.gov/21990298/

The Journal of Clinical Endocrinology & Metabolism 87 (2002): 1687–1691
Selenium Supplementation in Patients with Autoimmune Thyroiditis Decreases Thyroid Peroxidase Antibodies
Gärtner R, Gasnier BC, Dietrich JW, et al.
https://pubmed.ncbi.nlm.nih.gov/11932269/

The Lancet 379 (2012): 1256–1268
Selenium and Human Health
Rayman MP
https://pubmed.ncbi.nlm.nih.gov/22381456/

Studi scientifici sull’assunzione orale di acqua di mare / acqua marina profonda

Journal of the International Society of Sports Nutrition 10 (2013): 7
Deep ocean mineral water accelerates recovery from physical fatigue
Hou C-W, Tsai Y-S, Jean W-H, et al.
https://www.tandfonline.com/doi/full/10.1186/1550-2783-10-7

Journal of the International Society of Sports Nutrition 11 (2014): 34
Deep mineral water accelerates recovery after dehydrating aerobic exercise: a randomized, double-blind, placebo-controlled crossover study
StasiuleL, CapkauskieneS, VizbaraiteD, StasiulisA
https://jissn.biomedcentral.com/articles/10.1186/1550-2783-11-34

Marine Drugs 17 (2019): 309
Oral Ingestion of Deep Ocean Minerals Increases High-Intensity Intermittent Running Capacity in Soccer Players after Short-Term Post-Exercise Recovery: A Double-Blind, Placebo-Controlled Crossover Trial
Higgins MF, Rudkin B, Kuo C-H
https://www.mdpi.com/1660-3397/17/5/309

International Journal of Environmental Research and Public Health 19 (2022): 9581
Seawater Hydration Modulates IL-6 and Apelin Production during Triathlon Events: A Crossover Randomized Study
González Acevedo O, Aragón-Vela J, De la Cruz Márquez JC, Marín MM, CasusoRA, Huertas JR
https://www.mdpi.com/1660-4601/19/15/9581

Nutrients 14 (2022): 581
Health Effects of Drinking Water Produced from Deep Sea Water: A Randomized Double-Blind Controlled Trial
Takeuchi H, YoshikaneY, Takenaka K, et al.
https://www.mdpi.com/2072-6643/14/3/581

Journal of the International Society of Sports Nutrition 13 (2016): 17
The impact of post-exercise hydration with deep-ocean mineral water on rehydration and exercise performance
Keen DA, ConstantopoulosE, KonhilasJP
https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0129-8

Nutrients 12 (2020): 2646
Drinking Refined Deep-Sea Water Improves the Gut Ecosystem with Beneficial Effects on Intestinal Health in Humans: A Randomized Double-Blind Controlled Trial
Takeuchi H, Higuchi K, YoshikaneY, et al.
https://www.mdpi.com/2072-6643/12/9/2646

Nutrients 14 (2022): 4609
Physiological Benefits and Performance of Sea Water Ingestion for Athletes in Endurance Events: A Systematic Review
Aragón-Vela J, Acevedo OG, Marín MM, De la Cruz Márquez JC, Huertas JR
https://www.mdpi.com/2072-6643/14/21/4609

Frontiers in Physiology 8 (2017): 1016
Deep Ocean Mineral Supplementation Enhances the Cerebral Hemodynamic Response during Physical Challenge and Post-exercise Recovery
Wei C-Y, Lin C-S, Tsai Y-S, et al.
https://www.frontiersin.org/articles/10.3389/fphys.2017.01016/full

Journal of Clinical Medicine 13 (2024): 2258
The Effects of Acute Deep Seawater Supplementation on the Nutritional Status in Endurance Athletes
Aragón-Vela J, Acevedo OG, De la Cruz Márquez JC, et al.
https://www.mdpi.com/2077-0383/13/8/2258

Studi scientifici su minerali colloidali (assunzione orale e sicurezza/efficacia correlata)

Journal of the International Society of Sports Nutrition 10 (2013): 7
Deep ocean mineral water accelerates recovery from physical fatigue
HouC-W, TsaiY-S, Jean W-H, et al.
https://www.tandfonline.com/doi/full/10.1186/1550-2783-10-7

Journal of the International Society of Sports Nutrition 13 (2016): 17
The impact of post-exercise hydration with deep-ocean mineral water on rehydration and exercise performance
Keen DA, Constantopoulos E, Konhilas JP
https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0129-8

medRxiv(preprint) (2023):
A first-in-human study in healthy subjects of the safety and pharmacokinetics of CNM-Au8, a suspension of catalytically active gold nanocrystals
Pope JE, Song D, TaubPR, et al.
https://www.medrxiv.org/content/10.1101/2023.05.11.23289871v1.full

Particle and Fibre Toxicology 18 (2021): 41
Repeated oral administration of low doses of silver nanoparticles in mice: tissue distribution and biological effects
Recordati C, De Maglie M, Bianchessi S, et al.
https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-021-00418-x

International Journal of Molecular Sciences 24 (2023): 8962
Impact of chronic oral administration of gold nanoparticles on offspring behaviorand maternal tissues in mice
Ivlieva AL, Kozlova AA, Yushkova EV, et al.
https://www.mdpi.com/1422-0067/24/10/8962

American Journal of Case Reports 20 (2019):
Colloidal Silver Ingestion Associated with Leukocytoclastic Vasculitis and Progressive Skin Argyria
Mohan N, et al.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6543947/

Studi scientifici sull’assunzione orale di acqua di mare / acqua marina profonda

Studi scientifici su minerali colloidali (assunzione orale e sicurezza/efficacia correlata)

Journal of the International Society of Sports Nutrition 10 (2013): 7
Deep ocean mineral water accelerates recovery from physical fatigue
HouC-W, TsaiY-S, Jean W-H, et al.
https://www.tandfonline.com/doi/full/10.1186/1550-2783-10-7

Journal of the International Society of Sports Nutrition 13 (2016): 17
The impact of post-exercise hydration with deep-ocean mineral water on rehydration and exercise performance
Keen DA, Constantopoulos E, Konhilas JP
https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0129-8

STEMQ10

Studi Scientifici su Alga Klamath (AFA)

JANA, 2, 2000, 50-58
Aphanizomenonflos-aquae increases NK cells: randomized crossover
Jensen GS et al.
https://pubmed.ncbi.nlm.nih.gov/

Cardiovasc RevascMed, 8, 2007, 189-202
AFA extract raises circulating CD34+ cells: randomized study
Drapeau C et al.
https://pubmed.ncbi.nlm.nih.gov/

J Med Food, 5, 2002, 79-87
Safety/tolerance of AFA consumption in humans
Rojas A et al.
https://pubmed.ncbi.nlm.nih.gov/

EurJ Nutr, 47, 2008, 375-382
Anti-inflammatory effects of AFA in healthy subjects: pilot clinical
Selmi C et al.
https://pubmed.ncbi.nlm.nih.gov/

NutrJ, 7, 2008, 26
Blue-green algae reduce inflammatory markers: clinical observation
Jensen GS et al.
https://pubmed.ncbi.nlm.nih.gov/

Nutrition, 20, 2004, 539-543
Antioxidant status after AFA: randomized trial
Pérez-Martínez A et al.
https://pubmed.ncbi.nlm.nih.gov/

Plant Foods Hum Nutr, 66, 2011, 363-369
AFA phycocyaninsand oxidative stress markers: human evaluation
León F et al.
https://pubmed.ncbi.nlm.nih.gov/

PhytotherRes, 24, 2010, 190-195
AFA supplementation improves lipid profile: randomized study
Ammar EM et al.
https://pubmed.ncbi.nlm.nih.gov/

Food Chem Toxicol, 50, 2012, 4105-4110
Monitoring microcystinsin commercial AFA products: human data
Salgado D et al.
https://pubmed.ncbi.nlm.nih.gov/

JANA, 4, 2001, 10-15
Immune modulation with AFA: open-label human study
Jensen GS et al.
https://pubmed.ncbi.nlm.nih.gov/

Oxidative Medicine and Cellular Longevity (2018):
Effects of the Aphanizomenonflos-aquae Extract (Klamin®) on a Neurodegeneration Cellular Model: Prevention of Oxidative Stress and Mitochondrial Dysfunction
Cecchini F, Capoccia E, Ferrara G, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166380/

Journal of Diabetes & Metabolic Disorders 14 (2015): 27
Consequences of Aphanizomenonflos-aquae (AFA) extract on antioxidant status and glycemiccontrol in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial
Montesanto A, Ghanbari M, Mashhadi NS, et al.
https://link.springer.com/article/10.1186/s40200-015-0177-7

International Journal for Vitamin and Nutrition Research 79 (2009): 117–123
Effect of a Klamath algae product (“AFA-B12”) on blood levels of vitamin B12 and homocysteine in vegan subjects: a randomized study
Baroni L, Goggi S, Battaglino R, et al.
https://article.imrpress.com/journal/IJVNR/79/2/10.1024/0300-9831.79.2.117/5da09c9f0fb1569d6dcc98299700c500.pdf

GynecologicalEndocrinology 25 (2009): 235–240
Effects of Klamath Algae extract on psychological disorders and depression in menopausal women: a randomized pilot study
Scoglio S, Benedetti S, Canino C, et al.
https://pubmed.ncbi.nlm.nih.gov/20938423/

Nutrients 13 (2021): 3445
Spasmolytic Effects of Aphanizomenonflosaquae (AFA) Extract on Human Distal Colon Mechanical Activity
Borgonetti V, Governa P, Biagi M, et al.
https://www.mdpi.com/2072-6643/13/10/3445

RenalFailure 30 (2008): 1065–1073
Evaluation of renoprotectiveeffect of Aphanizomenonflos-aquae against cisplatin-induced oxidative stress in rats
Abdel-Daim MM, AbdeenA, JalouliM, et al.
https://www.tandfonline.com/doi/full/10.1080/08860220802134730

DrugTargets Insights 10 (2016): 27–34
InhibitoryeffectsofAphanizomenonflos-aquaeconstituentsonUDP-glucosedehydrogenase activityand cancer cellproliferation
Pisani LP, Maschio DA, de Oliveira C, et al.
https://www.tandfonline.com/doi/full/10.3109/14756366.2016.1149478

Cells 12 (2023): 2706
Positive Impacts of Aphanizomenonflosaquae Extract on Obesity and Related Disorders in Mice Fed a High-Fat Diet
Morselli LL, Scoglio S, Benedetti S, et al.
https://www.mdpi.com/2073-4409/12/23/2706

Oxidative Medicine and Cellular Longevity (2023):
Aphanizomenonflos-aquae (AFA) Extract Prevents HFD-induced Neurodegeneration in Mice: Behavioraland Biochemical Analysis
Scoglio S, Benedetti S, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003388/

Marine Drugs 23 (2025): 225
Aphanizomenonflos-aquae: A Biorefinery for Health and Energy
Pane C, Villecco D, Giordano M, et al.
https://www.mdpi.com/1660-3397/23/6/225

STUDI SCIENTIFICI SU ALGA SPIRULINA

Not specified (PubMed indexed) (2022):
Effects of Spirulina maxima Extract on Memory Improvement in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Authors not fully listed in abstract
https://pubmed.ncbi.nlm.nih.gov/36145090/

BMC Complementary Medicine and Therapies 24 (2024): Article 109
Effects of Spirulina supplementation in patients with ulcerative colitis: a double-blind, placebo-controlled randomized trial
Authors from BMC Complement Med Ther
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-024-04400-w

Frontiers in Immunology 15 (2024): 1332425
Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19: a randomized controlled trial
AghasadeghiMR, Zaheri BirganiMA, JamalimoghadamsiyahkaliS, et al.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1332425/full

European Review for Medical and Pharmacological Sciences 21 (2017): 2473–2481
Spirulina maxima in obesity: a randomized study
SzulińskaM, et al.
https://www.europeanreview.org/wp/wp-content/uploads/2473-2481-Spirulina-maxima-in-obesity-a-randomized-study.pdf

Unspecified PDF source (Semantic Scholar) (Unknown):
A randomized study to establish the effects of spirulina in type 2 diabetic patients
Lee EH, et al.
https://pdfs.semanticscholar.org/c3d2/72215a29d843ac9e0fda32022548e1a6f07c.pdf

Current Respiratory Medicine Reviews 21 (2025): 179–188
Therapeutic Efficacy of Spirulina Algae and N-Acetylcysteine in COVID-19 Hospitalized Patients: A Randomized Phase II Clinical Trial
Attaran D, Baniasad A, Najafzadeh MJ, et al.
https://dx.doi.org/10.2174/011573398X304275240626050005

Studi scientifici sul Resveratrolo

Neurology 85 (2015): 1383–1391
A randomized, placebo-controlled, double-blind, multicenter52-week phase 2 trial of resveratrol in individuals with mild to moderate Alzheimer disease
Turner RS, Thomas RG, Craft S, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626244/

PubMed (2023):
A randomized trial of resveratrol supplement affecting lipid profile in adults
Not fully listed
https://pubmed.ncbi.nlm.nih.gov/36771199/

The Journal of Clinical Endocrinology & Metabolism 95 (2010): E1–E8
Anti-inflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatumcontaining resveratrol
Ghanim H, Sia CL, AbuayshehS, et al.
https://www.clinicaltherapeutics.com/article/S0149-2918(18)30245-5/abstract

Pharmacological Research 111 (2016): 896–905
Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients: A randomized, double blind, placebo-controlled trial
Bo S, Ponzo V, CicconeG, et al.
https://www.clinicaltherapeutics.com/article/S0149-2918(18)30245-5/abstract

Digestive and Liver Disease 47 (2015): 226–232
Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial
Chen S, ZhaoX, RanL, et al.
https://www.clinicaltherapeutics.com/article/S0149-2918(18)30245-5/abstract

Diabetes 62 (2013): 1186–1195
High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
Poulsen MM, Vestergaard PF, Clasen BF, et al.
https://www.clinicaltherapeutics.com/article/S0149-2918(18)30245-5/abstract

Cell Metabolism 14 (2011): 612–622
Calorie restriction–like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
TimmersS, KoningsE, BiletL, et al.
https://www.clinicaltherapeutics.com/article/S0149-2918(18)30245-5/abstract

PMC (2018):
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
Not fully listed
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835393

Scientific Reports 12 (2022): 13920
Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19)
Authors listed in article
https://www.nature.com/articles/s41598-022-13920-9

Frontiers in Endocrinology (2024):
The efficacy of resveratrol supplementation on inflammation and oxidative stress in T2DM patients
SeyyedebrahimiS, KhodabandehlooH, Nasli Esfahani E, MeshkaniR
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1463027/full

Studi scientifici sul Coenzima Q10

Journal of Clinical Medicine 13 (2024): 3741
Effect of Coenzyme Q10 on Physical Performance in Older Adults with Statin-Associated Asthenia: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Fogacci F, Giovannini M, Tocci G, Imbalzano E, Borghi C, Cicero AFG
https://www.mdpi.com/2077-0383/13/13/3741

eClinicalMedicine 53 (2022): 101619
Effects of Coenzyme Q10 supplementation on glycemiccontrol: A systematic review and meta-analysis of 40 randomized controlled trials
Deng Y, Wang S, Cai Y, Zheng Y, Cheng L, Liu S, et al.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00332-7/fulltext

Trials 25 (2024): 284
Coenzyme Q10 supplementation in burn patients: a double-blind, placebo-controlled trial
NouruziS, Khoshnam-Rad N, Nouri M, et al.
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08006-y

Antioxidants 9 (2020): 341
Coenzyme Q10 supplementation improves adipokine levels and reduces oxidative stress in nonalcoholicfatty liver disease: A randomized double-blind placebo-controlled trial
FarhangiMA, Alipour B, JafarvandE, KhoshbatenM
https://www.mdpi.com/2076-3921/9/4/341

JAMA Neurology 71 (2014): 543–552
A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: The QE3 Study
Beal MF, Oakes D, ShoulsonI, et al.
https://jamanetwork.com/journals/jamaneurology/fullarticle/1851409

Journal of the American Heart Association 7 (2018): e009835
Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials
QuH, Meng Y, Chai H, et al.
https://www.ahajournals.org/doi/10.1161/JAHA.118.009835

Studi scientifici su L-Arginina

American Journal of Hematology88 (2013): 1–7
L-Arginine supplementation in sickle cell disease: a double-blind randomized clinical trial
Morris CR, Kuypers FA, LavrishaL, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378076/

International Journal of Molecular Sciences 15 (2014): 10540–10553
L-Arginine supplementation reduces oxidative stress and improves vascular function in obese patients with prediabetes
Bogdanski P, SuliburskaJ, SzulinskaM, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213784/

Nutrients 14 (2022): 4984
Effects of L-Arginine Supplementation on Physical Performance and Endothelial Function in Long COVID Patients
Buonocore D, Rucci P, Dalle Carbonare M, et al.
https://www.mdpi.com/2072-6643/14/23/4984

Nutrition, Metabolism and Cardiovascular Diseases 30 (2020): 1220–1230
Effect of L-Arginine supplementation on lipid profile: A meta-analysis of randomized controlled trials
Mohammadi H, BahreynianM, AbbasalizadFarhangiM, et al.
https://pubmed.ncbi.nlm.nih.gov/31922465/

Journal of Endocrinological Investigation 44 (2021): 1059–1066
Long-term high-dose L-arginine supplementation improves blood pressure and vascular function in patients with hypertension
Barbieri M, Rizzo MR, Manzella D, et al.
https://link.springer.com/article/10.1007/s40618-021-01704-3

BMC Cardiovascular Disorders 24 (2024): 4318
L-Arginine reduces inflammatory markers in patients undergoing coronary artery bypass surgery
Pourafkari L, Ghaffari S, Tajlil A, et al.
https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-024-04318-8

eClinicalMedicine 69 (2024): 100531
L-Arginine therapy in spinocerebellar ataxia type 6: a clinical and molecular study
Coppola G, Iannaccone S, Mantuano E, et al.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00531-5/fulltext

Circulation 93 (1996): 2135–2139
Oral L-arginine improves endothelial function in patients with coronary artery disease
CeremuzynskiL, Chamiec T, Herbaczynska-Cedro K
https://www.ahajournals.org/doi/10.1161/01.CIR.93.12.2135

Journal of Chiropractic Medicine 15 (2016): 184–189
Therapeutic Benefits of L-Arginine: An Umbrella Review of Meta-Analyses
McRae MP
https://www.sciencedirect.com/science/article/abs/pii/S1556370716300025

ClinicalNutrition 39 (2020): 303–313
The effect of L-arginine supplementation on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials
Zarezadeh M, Mansouri A, Askari G, et al.
https://pubmed.ncbi.nlm.nih.gov/31780028/

Studi scientifici su L-Carnitina

Obesity Reviews 17 (2016): 970–976
Effects of L-carnitine supplementation on weight loss and body composition: a systematic review and meta-analysis of randomized controlled trials
PooyandjooM, NouhiM, Shab-Bidar S, et al.
https://pubmed.ncbi.nlm.nih.gov/32359762/

Frontiers in Pharmacology 14 (2023): 10148537
Efficacy and safety of L-carnitine supplementation on nonalcoholicfatty liver disease: a meta-analysis of randomized controlled trials
Yang D, Zhang X, Zhang H, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148537/

Frontiers in Nutrition 10 (2023): 1134162
A randomized clinical trial to evaluate the efficacy of L-carnitine L-tartrate to modulate the effects of SARS-CoV-2 infection
Cicero AFG, Fogacci F, Borghi C, et al.
https://www.frontiersin.org/articles/10.3389/fnut.2023.1134162/full

Journal of the International Society of Sports Nutrition 17 (2020): 52
The bright and the dark sides of L-carnitine supplementation: a systematic review
FieldingR, RiedeL, Lugo JP, et al.
https://jissn.biomedcentral.com/articles/10.1186/s12970-020-00377-2

European Journal of Clinical Nutrition 72 (2018): 593–599
Efficacy of L-carnitine supplementation for improving lean body mass in cancer patients: a double-blind randomized clinical trial
Gramignano G, Lusso MR, Madeddu C, et al.
https://www.nature.com/articles/s41430-018-0348-y

Journal of Functional Morphology and Kinesiology 6 (2021): 93
Effects of L-carnitine supplementation on strength, endurance, and physical performance: a systematic review
Giamberardino MA, Bini G, Fedele V, et al.
https://www.mdpi.com/2411-5142/6/4/93

Frontiers in Nutrition 10 (2023): 1214734
The effect of L-carnitine supplementation on lipid profile in adults: a systematic review and meta-analysis of randomized controlled trials
Derosa G, Maffioli P, D’Angelo A, et al.
https://www.frontiersin.org/articles/10.3389/fnut.2023.1214734/full

Studi scientifici su Astaxantina

Antioxidants 10 (2021): 1289
Effects of Astaxanthin on Skin Health: A Systematic Review of Clinical Studies
ChureepornC, Watanabe F, Asami T, NiiyaT
https://www.mdpi.com/2076-3921/10/8/1289

Journal of Functional Foods 82 (2021): 104488
Astaxanthin supplementation improves lipid profiles and oxidative stress: a systematic review and meta-analysis
SaeidifardF, Rezaei H, Vafa M
https://doi.org/10.1016/j.jff.2021.104488

International Journal of Sports Medicine 32 (2011): 882–888
Astaxanthin supplementation enhances exercise performance and fat metabolism in trained individuals: a randomized controlled trial
Earnest CP, Lupo M, White KM, Church TS
https://pubmed.ncbi.nlm.nih.gov/21894398/

Journal of Clinical Biochemistry and Nutrition 51 (2012): 102–107
Astaxanthin attenuates oxidative stress and inflammation in patients with cardiovascular disease risk factors: a randomized, double-blind, placebo-controlled trial
YoshidaH, YanaiH, Ito K, et al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408806/

Molecules 25 (2020): 4348
The neuroprotective effects of astaxanthin: evidence from clinical studies
GrimmigB, Kim SH, Nash K, Bickford PC
https://www.mdpi.com/1420-3049/25/19/4348

Journal of Clinical Biochemistry and Nutrition 58 (2016): 61–67
Astaxanthin improves cognitive function in healthy older adults: a double-blind randomized controlled trial
Katagiri M, Satoh A, Tsuji S, ShirasawaT
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728679/

Journal of Clinical Therapeutics & Medicines 18 (2002): 73–88
Astaxanthin supplementation delays fatigue and improves muscle recovery in athletes
SawakiK, YoshigiH, Aoki K, KoikawaN
https://astareal.com/assets/files/Astaxanthin_Athletes.pdf

Journal of Traditional Medicines 22 (2005): 1–6
Effects of astaxanthin on eye fatigue in healthy subjects: a randomized, double-blind, placebo-controlled study
NagakiY, HayasakaS, Yamada T, et al.
https://www.jstage.jst.go.jp/article/jtm1992/22/2/22_2_66/_pdf

Journal of Clinical Biochemistry and Nutrition 56 (2015): 102–107
Astaxanthin protects skin from UV-induced aging: a clinical study
Tominaga K, Hongo N, Karato M, Yamashita E
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429538/

Journal of Clinical Therapeutics & Medicines 27 (2011): 153–160
A randomized double-blind placebo-controlled study of astaxanthin supplementation for cognitive performance in middle-aged and older individuals
SatohA, TsujiS, OkadaY, Murakami N
https://astareal.com/assets/files/Astaxanthin_Cognition.pdf

Studi scientifici su Luteina

Investigative Ophthalmology & Visual Science 55 (2014): 8583–8589
A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on PhotostressRecovery, Glare Disability, and Chromatic Contrast
Hammond BR, Fletcher LM, RoosF, Wittwer J, Schalch W
https://doi.org/10.1167/iovs.14-15573

Acta Ophthalmologica 95 (2017): e763–e769
Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 Fatty Acids on Macular Pigment Optical Density in Elderly Individuals
Merle BMJ, BuaudB, KorobelnikJF, et al.
https://doi.org/10.1111/aos.13408

Investigative Ophthalmology & Visual Science 46 (2005): 444–449
Lutein Supplementation over a One-Year Period in Early AMD Might Increase Macular Pigment Optical Density
BerendschotTTJM, GoldbohmRA, Klöpping-KetelaarsIAA, et al.
https://iovs.arvojournals.org/article.aspx?articleid=2166000

Investigative Ophthalmology & Visual Science 54 (2013): 3780
A randomized trial of supplementation with lutein, zeaxanthin, omega-3 fatty acids and antioxidants for increasing macular pigment optical density: the LIMPIA Study
KorobelnikJF, DelyferMN, Rougier MB, et al.
https://iovs.arvojournals.org/article.aspx?articleid=2148589

Journal of Ophthalmology 2015 (2015): 564738
Effect of Supplemental Lutein and Zeaxanthin on Serum, Macular Pigment, and Visual Function in Early AMD Patients
Chung HY, Rasmussen HM, Johnson EJ
https://onlinelibrary.wiley.com/doi/10.1155/2015/564738

Frontiers in Nutrition 11 (2024): 1422468
Effect of supplementation with lutein, zeaxanthin, and omega-3 fatty acids on visual and macular outcomes (LZO trial)
Reay A, Cameron JD, Luinstra A, et al.
https://www.frontiersin.org/articles/10.3389/fnut.2024.1422468/full

JAMA Ophthalmology 135 (2017): 1251–1259
Supplementation with lutein, zeaxanthin, and omega-3 fatty acids for age-related macular degeneration: the AREDS2 Study
AREDS2 Research Group
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2654968

Optometry -Journal of the American Optometric Association 75 (2004): 216–230
Randomized double-blind placebo-controlled study of lutein and antioxidants on visual function in healthy eyes
Richer S, Devenport J, Lang JC
https://www.sciencedirect.com/science/article/abs/pii/S1529183904700494

Clinical Nutrition 27 (2008): 218–227
A randomized trial of lutein and antioxidants on visual function in healthy eyes
Olmedilla B, Granado F, Blanco I, Vaquero M
https://www.sciencedirect.com/science/article/abs/pii/S0261561408000186

Nutrients 12 (2020): 2966
Clinical Effects of Dietary Supplementation of Lutein with High Bioavailability
Nakamura A, Sugiura Y, Sato K, et al.
https://www.mdpi.com/2072-6643/12/10/2966

Studi scientifici su Vitamina D3 (colecalciferolo)

The New England Journal of Medicine 380 (2019): 33–44
Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
Manson JE, Cook NR, Lee I-M, et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa1809944

The New England Journal of Medicine 387 (2022): 299–309
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
LeBoffMS, Chou SH, Ratliff JC, et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa2202106

The New England Journal of Medicine 381 (2019): 520–530
Vitamin D Supplementation to Prevent Type 2 Diabetes (D2d)
Pittas AG, Dawson-Hughes B, Sheehan P, et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa1900906

BMJ 356 (2017): i6583
Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of individual participant data
MartineauAR, JolliffeDA, Hooper RL, et al.
https://www.bmj.com/content/356/bmj.i6583

JAMA Cardiology 2 (2017): 608–616
Monthly High-Dose Vitamin D Supplementation and Cardiovascular Disease
ScraggR, Stewart AW, WaayerD, et al.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2619183

Archives of Internal Medicine 167 (2007): 1730–1737
Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials
AutierP, Gandini S
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/413209

BMJ 339 (2009): b3692
Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
Bischoff-Ferrari HA, Willett WC, Wong JB, et al.
https://www.bmj.com/content/339/bmj.b3692

The Lancet Diabetes & Endocrinology 4 (2016): 393–402
Maternal vitamin D supplementation during pregnancy and offspring bone mass at birth (MAVIDOS): a randomised double-blind, placebo-controlled trial
Harvey NC, HolroydC, NtaniG, et al.
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(16)30044-9/fulltext

The Lancet Diabetes & Endocrinology 9 (2021): 276–292
Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of randomised controlled trials (updated)
JolliffeDA, Greenberg L, Hooper RL, et al.
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00051-6/fulltext

JAMA 324 (2020): 471–480
Effect of Long-term Vitamin D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms: A Randomized Clinical Trial
OkerekeOI, Reynolds CF, MischoulonD, et al.
https://jamanetwork.com/journals/jama/fullarticle/2768978

STUDI SCIENTIFICI SU IALU-COLL PLUS

Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women: a randomized controlled trial
Autori: König D, OesserS, ScharlaS, ZdzieblikD, MachmannL, Welle S
Rivista: Nutrients, 2018
Link: https://doi.org/10.3390/nu10040497

Effects of specific collagen peptides on bone metabolism: a review of clinical trials in osteopenicand osteoporotic women
Autori: ZdzieblikD, König D, OesserS
Rivista: Nutrients, 2021
Link: https://doi.org/10.3390/nu13092943

Overview of collagen peptide supplementation and bone metabolism in postmenopausal women: current evidence and clinical perspectives
Autori: Frontiers Editorial Team
Rivista: Frontiers in Nutrition, 2025
Link: https://www.frontiersin.org/articles/10.3389/fnut.2025.1526892

Hydrolyzedcollagen supplementation improves knee pain and function in osteoarthritis: a double-blind randomized controlled trial
Autori: Carrillo-Norte JA, Alonso J, Fernández-García D, et al.
Rivista: Clinical Nutrition ESPEN, 2025
Link: https://doi.org/10.1016/j.clnesp.2024.10.007

UCLA researchers find collagen peptides improve bone mineral density in women with osteopenia
Autori: UCLA Health Research Summary
Rivista: UCLA Health, 2021
Link: https://www.uclahealth.org

Oral hydrolyzedcollagen improves knee osteoarthritis symptoms: a double-blind randomized controlled trial
Autori: Kumar S, Sugihara F, Suzuki K, et al.
Rivista: Journal of the Science of Food and Agriculture, 2015
Link: https://doi.org/10.1002/jsfa.6530

Efficacy and safety of collagen peptides in knee osteoarthritis: a systematic review and meta-analysis
Autori: Lin C-R, Pan C-H, Lin Y-L, et al.
Rivista: Journal of Orthopaedic Surgery and Research, 2023
Link: https://doi.org/10.1186/s13018-023-03749-0

Specific bioactive collagen peptides reduce joint discomfort: a randomized controlled trial
Autori: Schulze C, Knaup S, Oesser S, König D
Rivista: International Journal of Environmental Research and Public Health, 2024
Link: https://doi.org/10.3390/ijerph21105423

Randomized controlled pilot study of hydrolyzedcollagen type II in subjects with knee osteoarthritis
Autori: Chen C-C, Wang C-H, Lin Y-H, et al.
Rivista: Nutrition Journal, 2023
Link: https://doi.org/10.1186/s12937-023-00875-y

Hydrolyzedfish cartilage for joint health: a randomized, double-blind, placebo-controlled study
Autori: Bouilly J, Giraud M, Combes M, et al.
Rivista: Foods, 2023
Link: https://doi.org/10.3390/foods12234215

Collagen hydrolysate supplementation for joint pain: a systematic review of clinical trials
Autori: ZdzieblikD, OesserS, König D
Rivista: Nutrients, 2023
Link: https://doi.org/10.3390/nu15051109

Nutrition and connective tissue adaptation: the role of collagen and vitamin C
Autori: Shaw G, Morton JP, Drust B, Close GL
Rivista: Nutrition Reviews, 2022
Link: https://doi.org/10.1093/nutrit/nuac027

Clinical effectiveness of collagen peptides for joint discomfort and connective tissue repair: a review
Autori: Sibilla S, Oesser S, Schunck M, et al.
Rivista: Heliyon, 2023
Link: https://doi.org/10.1016/j.heliyon.2023.e17354

Fish-derived hydrolyzedcollagen on wrinkles and elasticity: randomized, triple-blind RCT
Autori: Evans M. et al. (2020)
Link: https://pubmed.ncbi.nlm.nih.gov/32799362/

Liquid fish collagen improves hydration, roughness and elasticity
Autori: Lee J.S. et al. (2024)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC11156766/

ONS with collagen peptides improves hydration and elasticity in older adults
Autori: Nomoto T. et al. (2020)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC7328867/

Oral collagen for skin anti-aging: systematic review and meta-analysis
Autori: Pu S.Y. et al. (2023)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/

Low-molecular-weightcollagenpeptide improvesskin parameters
Autori: Kim D.U. et al. (2018)
Link: https://pubmed.ncbi.nlm.nih.gov/29949889/

Collagen peptide NS improves hydration and elasticity
Autori: Lee M. et al. (2023)
Link: https://pubs.rsc.org/en/content/articlehtml/2023/fo/d2fo02958h

Freshwater marine collagen—efficacy and safety
Autori: Evans M. et al. (2021)
Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.13676

Meta-analysis of collagen supplements on skin aging outcomes
Autori: Myung S.K. et al. (2025)
Link: https://www.amjmed.com/article/S0002-9343%2825%2900283-9/abstract

Hydrolyzedsea-fish collagen ready-to-drink: randomized study
Autori: WunnooS. et al. (2025)
Link: https://www.mdpi.com/2413-4155/7/4/134

Effects of hydrolyzedcollagen supplementation on skin aging: a systematic review and meta-analysis
Autori: Roseane B de Miranda, Patricia Weimer, Rochele C Rossi (2021)
Link: https://pubmed.ncbi.nlm.nih.gov/33742704/

Marine collagen: a promising biomaterial for wound healing, skin anti-aging, and bone regeneration
Autori: Sarah Geahchan, Parnian Baharlouei, Azizur Rahman (2022)
Link: https://pubmed.ncbi.nlm.nih.gov/35049916/

Oral supplementation with hydrolyzedfish cartilage improves morphological and structural characteristics of skin
Autori: Patricia M.B.G.M. Campos et al. (2021)
Link: https://pubmed.ncbi.nlm.nih.gov/34443468/

A randomized, triple-blind, placebo-controlled, parallel study to evaluate efficacy of a freshwater marine collagen
Autori: MalkanthiEvans, Erin D Lewis, NisrineZakaria, et al. (2021)
Link: https://pubmed.ncbi.nlm.nih.gov/32799362/

Collagen supplementation for skin health: a mechanistic systematic review
Autori: Meisam Barati, Masoumeh Jabbari, Roya Navekar, et al. (2020)
Link: https://pubmed.ncbi.nlm.nih.gov/32436266/

Acido Ialuronico Orale – Studi Scientifici

Oral hyaluronan relieves wrinkles and improves dry skin
Autori: Hsu T.F., Su Z.R., Hsieh Y.H., Wang M.F., Oe M., Matsuoka R., Masuda Y. (2021)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8308347/

Ingested HA moisturizes dry skin: randomized, double-blind
Autori: Kawada C., Yoshida T., Yoshida H., Matsuoka R., Sakamoto W., OdanakaW., Sato T., Yamasaki T., Kanemitsu T., Masuda Y., UrushibataO. (2014)
Link: https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-70

Oral HA solution improves skin hydration and wrinkles
Autori: Göllner I., Voss W., Kammerer S. (2017)
Link: https://journals.sagepub.com/doi/10.1177/2156587217743640

Oral HA to improve skin—randomized clinical study
Autori: Gao Y.R., Wang R.P., Zhang L., Fan Y., Luan J., Liu Z., Yuan C. (2023)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC10661223/

Oral low-MW liquid HA in knee OA: RCT
Autori: Wang S.J., Wang Y.H., Huang L.C. (2021)
Link: https://pubmed.ncbi.nlm.nih.gov/33592868/

Review: oral hyaluronan relieves knee pain
Autori: Oe M., Tashiro T., Yoshida H., Nishiyama H., Masuda Y., Maruyama K., KoikedaT., MaruyaR., Fukui N. (2016)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4729158/

Oral sodium hyaluronate relieves knee discomfort: 12-week RCT
Autori: SugiyamaK., OeM., TanakaT., MatsuokaR., Takeda Y., KimuraM., OdaniK. (2023)
Link: https://www.spandidos-publications.com/10.3892/etm.2023.12352

Oralfull-spectrumHA + topicalHA improvesskinaging: multicenter RCT
Autori: NobileV., RovedaG., Sparta E., TursiE.F. (2025)
Link: https://www.mdpi.com/2079-9284/12/2/52

MSM (Metilsulfonilmetano) – Studi Scientifici

MSM in knee osteoarthritis: RCT
Autori: Kim L.S., Axelrod L.J., Howard P., Buratovich N., Waters R.F. (2006)
Link: https://www.oarsijournal.com/article/S1063-4584(05)00285-2/fulltext

MSM supplementation in knee OA: randomized controlled
Autori: Debbi E.M., Agar G., Fichman G., Bar Ziv Y., KardoshR., Halperin N., Elbaz A., Beer Y., Debi R. (2011)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3141601/

MSM on exercise-induced muscle damage/oxidative stress
Autori: WitheeE.D., Tippens K.M., Dehen R., Tibbitts D., Hanes D., Zwickey H. (2017)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC5521097/

MSM and exercise recovery markers
Autori: Kalman D.S., Feldman S., Scheinberg A.R., Krieger D.R., Bloomer R.J. (2012)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3507661/

MSM reduces allergic rhinitis symptoms after challenge
Autori: Hewlings S.J., Kalman D.S. (2018)
Link: https://pubmed.ncbi.nlm.nih.gov/30497995/

MSM improves knee/systemic health in mild knee pain
Autori: Toguchi A. et al. (2023)
Link: https://www.mdpi.com/2072-6643/15/13/2995

Open-label MSM for seasonal allergic rhinitis
Autori: BarragerE. et al. (2002)
Link: https://www.liebertpub.com/doi/10.1089/107555302317371451

AcuteMSM reducesexercise-inducedpainvsplacebo
Autori: KalmanD. et al. (2013)
Link: https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.27.1_supplement.1076.7

MSM-containing nutraceutical improves facial skin aesthetics
Autori: Guaitolini E. et al. (2019)
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6508480/

Supplements incl. MSM and collagen: 12-week, four-way RCT
Autori: PogačnikT. et al. (2023)
Link: https://www.sciencedirect.com/science/article/pii/S1756464623004383

Studi Scientifici – Centella asiatica

TTFCA in chronic venous hypertension: randomized study
Autori: Incandela L. et al.
Rivista: Angiology
Anno: 2001
Link: https://pubmed.ncbi.nlm.nih.gov/11666128/

Dose-response trial of TTFCA in CVI
Autori: Incandela L. et al.
Rivista: Angiology
Anno: 2001
Link: https://journals.sagepub.com/doi/10.1177/000331970105202S12

Systematic review: Centella asiatica for CVI
Autori: Chong N.J., Aziz Z.
Rivista: Evidence-Based Complementary and Alternative Medicine
Anno: 2013
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3594936/

Topical gel for cellulite with Centella: double-blind RCT
Autori: Dupont E. et al.
Rivista: Clinical, Cosmetic and Investigational Dermatology
Anno: 2014
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3933246/

Systematic review: Centella and wound healing
Autori: Arribas-López E. et al.
Rivista: International Journal of Environmental Research and Public Health
Anno: 2022
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC8956065/

Phase-1 RCT of Centellaextract in older adults
Autori: Wright K.M. et al.
Rivista: Nutrients
Anno: 2022
Link: https://pubmed.ncbi.nlm.nih.gov/35204098/

Assessment report on Centella asiatica herba
Autori: EMA HMPC
Rivista: European Medicines Agency
Anno: 2022
Link: https://www.ema.europa.eu/en/documents/herbal-report/assessment-report-centella-asiatica-l-urb-herba-revision-1_en.pdf

Systematic review on cognition with Centella
Autori: PuttarakP. et al.
Rivista: Journal of Ethnopharmacology
Anno: 2017
Link: https://pubmed.ncbi.nlm.nih.gov/28878245/

UP1307 cream incl. Centella improves cellulite
Autori: Yimam M. et al.
Rivista: Journal of Clinical and Aesthetic Dermatology
Anno: 2018
Link: https://jcadonline.com/august-2018-cellulite/

Topical Centella in wound healing—clinical evidence
Autori: Witkowska K. et al.
Rivista: Pharmaceutics
Anno: 2024
Link: https://www.mdpi.com/1999-4923/16/10/1252

Studi Scientifici – Zinco

Zinc lozenges and the common cold: a meta-analysis
Autori: Hemilä H.
Rivista: Open Forum Infectious Diseases
Anno: 2017
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC5418896/

Oral zinc in childhood diarrhea: randomized trials
Autori: Bhutta Z.A. et al.
Rivista: American Journal of Clinical Nutrition
Anno: 2000
Link: https://www.sciencedirect.com/science/article/pii/S0002916523069149

Lower-dose zinc for childhood diarrhea—randomized controlled trial
Autori: Dhingra U. et al.
Rivista: New England Journal of Medicine
Anno: 2020
Link: https://www.nejm.org/doi/full/10.1056/NEJMoa1915905

Oral zinc sulfatein acne vulgaris: double-blind trial
Autori: Verma K.C. et al.
Rivista: Acta Dermato-Venereologica
Anno: 1980
Link: https://pubmed.ncbi.nlm.nih.gov/6163281/

Antioxidants + zinc reduce progression to advanced age-related macular degeneration (AREDS)
Autori: AREDS Research Group
Rivista: Archives of Ophthalmology
Anno: 2001
Link: https://pubmed.ncbi.nlm.nih.gov/11594942/

Zinc in depression: meta-analysis of RCTs and cohorts
Autori: YosaeeS. et al.
Rivista: Journal of Affective Disorders
Anno: 2022
Link: https://pubmed.ncbi.nlm.nih.gov/32829928/

Zinc lozenges shorten common cold duration: review and meta-analysis
Autori: Hemilä H.
Rivista: Open Respiratory Medicine Journal
Anno: 2011
Link: https://openrespiratorymedicinejournal.com/VOLUME/5/PAGE/51/ABSTRACT/

Zinc for acute and persistent watery diarrhea: meta-analysis
Autori: Ali A.A. et al.
Rivista: Journal of Global Health
Anno: 2024
Link: https://pubmed.ncbi.nlm.nih.gov/39641338/

Zinc supplementationreducesBeck depressionscores
Autori: RanjbarE. et al.
Rivista: Nutritional Neuroscience
Anno: 2013
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3796297/

Micronutrients in AMD—effects of zinc and antioxidants (AREDS2)
Autori: AREDS2 Research Group
Rivista: Ophthalmology
Anno: 2013
Link: https://www.sciencedirect.com/science/article/pii/S2161831323002211

Studi Scientifici – Magnesio

Magnesium supplementation for primary insomnia in elderly: randomized controlled trial
Autori: Abbasi B et al.
Rivista: Journal of Research in Medical Sciences
Anno: 2012
Link: https://pubmed.ncbi.nlm.nih.gov/23853635/

Meta-analysis of randomized controlled trials: magnesium lowers blood pressure
Autori: Zhang X et al.
Rivista: Hypertension
Anno: 2016
Link: https://pubmed.ncbi.nlm.nih.gov/27380488/

Intravenous magnesium sulfatefor acute migraine: randomized controlled trial
Autori: Bigal ME, Bordini CA, Speciali JG.
Rivista: Cephalalgia
Anno: 2002
Link: https://pubmed.ncbi.nlm.nih.gov/11972586/

Oral magnesium in migraine prophylaxis: randomized controlled trial
Autori: Peikert A, WilimzigC, Köhne-Volland R.
Rivista: Cephalalgia
Anno: 1996
Link: https://pubmed.ncbi.nlm.nih.gov/8734827/

Magnesium supplementation for depression: randomized clinical trial
Autori: TarletonEK, LittenbergB.
Rivista: PLoSOne
Anno: 2017
Link: https://pubmed.ncbi.nlm.nih.gov/28654669/

Magnesium and metabolic syndrome components: randomized controlled trial
Autori: Navarrete-Cortes A et al.
Rivista: Magnesium Research
Anno: 2014
Link: https://pubmed.ncbi.nlm.nih.gov/25215132/

Magnesium supplementation and glycemiccontrol in type 2 diabetes: meta-analysis
Autori: Rozga M et al.
Rivista: Nutrients
Anno: 2020
Link: https://pubmed.ncbi.nlm.nih.gov/32531956/

Magnesium supplementation reduces CRP and improves lipid profile in type 2 diabetes: randomized trial
Autori: Yousefi Rad E et al.
Rivista: Biological Trace Element Research
Anno: 2016
Link: https://pubmed.ncbi.nlm.nih.gov/26404386/

Magnesium citrate improves premenstrual syndrome symptoms: double-blind randomized controlled trial
Autori: Walker AF et al.
Rivista: Journal of Women’s Health
Anno: 1998
Link: https://pubmed.ncbi.nlm.nih.gov/9836532/

Oral magnesium improves insulin sensitivity: randomized controlled trial
Autori: Guerrero-Romero F, Rodríguez-Morán M.
Rivista: Diabetes & Metabolism
Anno: 2004
Link: https://pubmed.ncbi.nlm.nih.gov/15223987/

Studi Scientifici – Vitamina B6

B-vitamins (including B6) slow brain atrophy in mild cognitive impairment: randomized controlled trial
Autori: Smith AD et al.
Rivista: Proceedings of the National Academy of Sciences (PNAS)
Anno: 2010
Link: https://pubmed.ncbi.nlm.nih.gov/20421489/

Vitamin B6 for nausea and vomiting of pregnancy: Cochrane systematic review
Autori: KorenG et al.
Rivista: Cochrane Database of Systematic Reviews
Anno: 2014
Link: https://pubmed.ncbi.nlm.nih.gov/25069545/

Vitamin B6 versus placebo for nausea in pregnancy: randomized controlled trial
Autori: Vutyavanich T et al.
Rivista: Obstetrics & Gynecology
Anno: 1995
Link: https://pubmed.ncbi.nlm.nih.gov/78003

Pyridoxine for premenstrual syndrome: systematic review
Autori: Wyatt KM et al.
Rivista: BMJ
Anno: 1999
Link: https://pubmed.ncbi.nlm.nih.gov/10231253/

Pyridoxine versus ginger for pregnancy nausea: randomized controlled trial
Autori: KashanianM et al.
Rivista: Journal of Maternal-Fetal& Neonatal Medicine
Anno: 2009
Link: https://pubmed.ncbi.nlm.nih.gov/19488997/

Pyridoxine for carpal tunnel syndrome: randomized controlled trial
Autori: De Souza A et al.
Rivista: Acta Neurologica Scandinavica
Anno: 1985
Link: https://pubmed.ncbi.nlm.nih.gov/3893374/

Vitamin B6 status and homocysteine lowering with folate/B12/B6: randomized trialmeta-analysis
Autori: Levine M et al.
Rivista: Stroke
Anno: 2010
Link: https://pubmed.ncbi.nlm.nih.gov/20413736/

Vitamin B6 supplementation and cognitive performance in seniors: randomized study
Autori: Foresi A et al.
Rivista: Nutritional Neuroscience
Anno: 2007
Link: https://pubmed.ncbi.nlm.nih.gov/17539405/

Vitamin B6 supplementation reduces depressive symptoms: randomized study
Autori: Lana A et al.
Rivista: British Journal of Nutrition
Anno: 2015
Link: https://pubmed.ncbi.nlm.nih.gov/26395416/

Vitamin B6 and immune markers in the elderly: randomized trial
Autori: Ellul P et al.
Rivista: Age and Ageing
Anno: 1999
Link: https://pubmed.ncbi.nlm.nih.gov/10459765/

Studi Scientifici – Vitamina C

Vitamin C for preventing and treating the common cold (Cochrane Review)
Autori: Hemilä H., Chalker E.
Rivista: Cochrane Database Syst Rev
Anno: 2013
Link: https://pubmed.ncbi.nlm.nih.gov/23440782/

Effects of vitamin C supplementation on blood pressure: meta-analysis of randomized controlled trials
Autori: JuraschekS.P., GuallarE., Appel L.J., Miller E.R.
Rivista: American Journal of Clinical Nutrition
Anno: 2012
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3325833/

CITRIS-ALI: High-dose intravenous vitamin C in sepsis-related ARDS
Autori: Fowler A.A. III, TruwitJ.D., Hite R.D., et al.
Rivista: JAMA
Anno: 2019
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6777268/

The roles of vitamin C in skin health: clinical overview
Autori: Pullar J.M., Carr A.C., Vissers M.C.M.
Rivista: Nutrients
Anno: 2017
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC5579659/

Effect of vitamin C on inflammation and metabolic markers: randomized controlled trial
Autori: ElluluM.S., Rahmat A., PatimahI., Khaza’aiH., Abed Y.
Rivista: European Journal of Clinical Nutrition
Anno: 2015
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4492638/

Vitamin C revisited (critically ill review)
Autori: Oudemans-van StraatenH.M., Spoelstra-de Man A.M.E., de Waard M.C.
Rivista: Critical Care
Anno: 2014
Link: https://ccforum.biomedcentral.com/articles/10.1186/s13054-014-0460-x

Guava or synthetic vitamin C reduces experimental gingivitis: randomized clinical trial
Autori: Amaliya A., Timmerman M.F., Abbas F., et al.
Rivista: Journal of Clinical Periodontology
Anno: 2018
Link: https://pubmed.ncbi.nlm.nih.gov/29757462/

Vitamin C and immune function: clinical synthesis
Autori: Carr A.C., Maggini S.
Rivista: Nutrients
Anno: 2017
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC5707683/

Vitamin C, the common cold, and iron absorption
Autori: Cook J.D., Monsen E.R.
Rivista: American Journal of Clinical Nutrition
Anno: 1977
Link: https://www.ajcn.org/content/30/2/235.full.pdf

Vitamin C improves fatigue scores: randomized crossover
Autori: Michels A.J., et al.
Rivista: Nutrients
Anno: 2015
Link: https://pubmed.ncbi.nlm.nih.gov/34476568/

Studi Scientifici – Bamboo / Silicio

Bambusa vulgaris leaf extract oil for atopic dermatitis: clinical case series
Autori: Len T.T., Nguyen P.H., Tran H.N., et al.
Rivista: Advances in Integrative Medicine
Anno: 2023
Link: https://www.sciencedirect.com/science/article/pii/S2667031323000763

Oral choline-stabilized orthosilicicacid (source of silicon) improves skin, hair, nails: randomized controlled trial
Autori: Barel A., CalommeM., Timchenko A., De Paepe K., Demeester N., Rogiers V., Clarys P., Vanden Berghe D.
Rivista: Archives of Dermatological Research
Anno: 2005
Link: https://pubmed.ncbi.nlm.nih.gov/16205932/

Silicon use for skin and hair: human data review
Autori: de Araújo L.A., AddorF.A.S., Campos P.M.B.G.M.
Rivista: Anais Brasileiros de Dermatologia
Anno: 2016
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4938278/

Human absorption of orthosilicicacid formulations
Autori: Boqué N., ArdévolA., Méndez M., BladéC., et al.
Rivista: Scientific Reports
Anno: 2021
Link: https://www.nature.com/articles/s41598-021-95220-2

Choline-stabilized orthosilicicacid improves skin surface and hair/nail brittleness
Autori: FeinbergC., Barel A., CalommeM., et al.
Rivista: Journal of the American Academy of Dermatology
Anno: 2004
Link: https://www.jaad.org/article/S0190-9622(04)02898-1/fulltext

Medicinal applications and safety of bamboo extracts: review
Autori: Panee J.
Rivista: Journal of Ethnopharmacology
Anno: 2015
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4659479/

Bamboo extract and hepatic biotransformingenzymes: pilot human study
Autori: Koide C.L.K., Collier A.C., Berry M.J., Panee J.
Rivista: Journal of Ethnopharmacology
Anno: 2011
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3471658/

Green tea + bamboo + selenium supplement improves hair quality: randomized controlled trial
Autori: Lacetera J., Rossi A., Gómez R., et al.
Rivista: Preprints.org
Anno: 2025
Link: https://www.preprints.org/frontend/manuscript/b9b5cb6f48115b80f32173fcd1810e0d/download_pub

Herbal mouthrinse randomized controlled trial; bamboo extract cited for antibacterial activity
Autori: Kim Y.R., Lee J.Y., Kim J.Y., et al.
Rivista: Scientific Reports
Anno: 2022
Link: https://www.nature.com/articles/s41598-022-15445-7

Silicon supplementation randomized controlled trial—additional citation
Autori: Barel A., CalommeM., et al.
Rivista: Archives of Dermatological Research
Anno: 2005
Link: https://pubmed.ncbi.nlm.nih.gov/16205932/

Studi scientifici per VTX

NADH – 10 studi scientifici (somministrazione orale)

P R Health Sci J. 2004;23(2):89–93.Comparison of oral nicotinamide adenine dinucleotide (NADH) versus conventional therapy for chronic fatigue syndrome M.L. Santaella; I. Font; O.M. Disdier.https://pubmed.ncbi.nlm.nih.gov/15377055/

Ann Allergy Asthma Immunol. 1999;82(2):185–191.Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome L.M. Forsyth; H.G. Preuss; A.L. MacDowell; L. Chiazze Jr; G.D. Birkmayer; J.A. Bellanti.https://pubmed.ncbi.nlm.nih.gov/10071523/

Wien Med Wochenschr. 2002;152(17–18):450–454.Stabilized NADH (ENADA) improves jet lag–induced cognitive performance deficit G.D. Birkmayer; G.G. Kay; E. Vürre.https://pubmed.ncbi.nlm.nih.gov/12385067/

Drugs Exp Clin Res. 2004;30(1):27–33.Treatment of Alzheimer’s disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study. V. Demarin; S.S. Podobnik; D. Storga-Tomić; G. Kay.https://pubmed.ncbi.nlm.nih.gov/15134388/

Rev Clin Esp. 2010;210(6):284–288.Nicotinamide adenine dinucleotide (NADH) in patients with chronic fatigue syndromeJ. Alegre; J.M. Roses; C. Javierre; A. Ruiz-Baqués; M.J. Segundo; T. Fernández de Sevilla.https://pubmed.ncbi.nlm.nih.gov/20447621/

Wien Klin Wochenschr. 2001;113(1–2):27–32.No evidence for cognitive improvement from oral nicotinamide adenine dinucleotide (NADH) in dementia M. Rainer; E. Kraxberger; M. Haushofer; H. Mucke; K.A. Jellinger. https://pubmed.ncbi.nlm.nih.gov/11459000/

Antioxid Redox Signal. 2015;22(8):679–685.Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? J. Castro-Marrero; M.D. Cordero; M.J. Segundo; N. Sáez-Francàs; N. Calvo; L. Román-Malo; L. Aliste; T. Fernández de Sevilla; J. Alegre.https://pubmed.ncbi.nlm.nih.gov/25386668/

Clin Nutr. 2016;35(4):826–834. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome: a randomized, controlled, double-blind trial. J. Castro-Marrero; N. Sáez-Francàs; M.J. Segundo; N. Calvo; M. Faro; L. Aliste; T. Fernández de Sevilla; J. Alegre. https://pubmed.ncbi.nlm.nih.gov/26212172/

Nutrients. 2021;13(8):2658. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with ME/CFS: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. J. Castro-Marrero; M.J. Segundo; M. Lacasa; A. Martínez-Martínez; R.S. Sanmartin Sentañes; J. Alegre-Martín.https://www.mdpi.com/2072-6643/13/8/2658

Acta Neurol Scand Suppl. 1993;146:32–35. Coenzyme nicotinamide adenine dinucleotide (NADH) treatment of Parkinson’s disease J.G. Birkmayer; K. Vrecko; D. Volc; W. Birkmayer.https://pubmed.ncbi.nlm.nih.gov/8101414/

Studi su PQQ (orale / umani / trial)

Effect of the Antioxidant Supplement Pyrroloquinoline Quinone (BioPQQ) on Cognitive Functions in Healthy Elderly SubjectsRivista: (non indicata con precisione nel riassunto)Autori: (studio con 20 mg PQQ/die per 12 settimane)Link: PubMed abstract: https://pubmed.ncbi.nlm.nih.gov/26782228/

Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt (mnemoPQQ®) intake on improving muscle strength and physical function in humanRivista: unknown (studio recente)Autori: (non tutti reperibili)Link: https://www.sciencedirect.com/science/article/pii/S1756464624000148

Metabolic and Biochemical Effects of Pyrroloquinoline QuinoneRivista: AntioxidantsAutori: (review che include studi umani)Link: https://www.mdpi.com/2076-3921/13/9/1027

Pyrroloquinoline Quinone disodium salt improves brain function in healthy adults (Food & Function study)Rivista: Food & FunctionAutori: (Ikemoto et al.)Link: report in pubblicazioni correlate Research Features+2ScienceDirect+2

Metabolic and Biochemical Effects of Pyrroloquinoline QuinoneRivista: AntioxidantsAutori: (review che include studi umani)Link: https://www.mdpi.com/2076-3921/13/9/1027

Journal of Nutritional Biochemistry, 24(12), 2013, 2076–2084
Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects
Harris CB; ChowanadisaiW; Mishchuk DO; Satre MA; SlupskyCM; Rucker RB
Link: https://pubmed.ncbi.nlm.nih.gov/24231099/

Functional Foods in Health and Disease, 2(8), 2012, 307–324
Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep
Nakano M; Yamamoto T; Okamura H; Tsuda A; KowatariY
Link: https://ffhdj.com/index.php/ffhd/article/view/81

Advances in Experimental Medicine and Biology, 876, 2016, 319–325
Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ) on Cognitive Functions
Itoh Y; Hine K; Miura H; UetakeT; Nakano M; Takemura N; Sakatani K
Link: https://pubmed.ncbi.nlm.nih.gov/26782228/

Advances in Experimental Medicine and Biology, 923, 2016, 215–222
Effects of Antioxidant Supplements (BioPQQ) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex
Nakano M; Murayama Y; Hu L; Ikemoto K; UetakeT; Sakatani K
Link: https://pubmed.ncbi.nlm.nih.gov/27526146/

Journal of the American Nutrition Association, 41(8), 2022, 796–809
Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study
ShiojimaY; M. Takahashi; R. Takahashi; Moriyama H; Bagchi D; Bagchi M; AkanumaM
Link: https://pubmed.ncbi.nlm.nih.gov/34415830/

Journal of Nutrition, Health & Aging, 28(8), 2024, Article 100287
The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial
Baltic S; Nedeljkovic D; Todorovic N; RanisavljevM; KorovljevD; CvejicJ; Ostojic J; LeBaron TW; TimmckeJ; StajerV; Ostojic SM
Link: https://pubmed.ncbi.nlm.nih.gov/38908296/

Journal of Nutritional Science and Vitaminology(Tokyo), 61(3), 2015, 241–246
Effects of Orally Administered Pyrroloquinoline Quinone Disodium Salt on Dry Skin Conditions in Mice and Healthy Female Subjects
Nakano M; Kamimura A; Watanabe F; Kamiya T; Watanabe D; Yamamoto E; FukagawaM; Hasumi K; Suzuki E
Link: https://www.jstage.jst.go.jp/article/jnsv/61/3/61_241/_article

Journal of Nutritional Science and Vitaminology(Tokyo), 61(3), 2015, 233–240
Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults
NakanoM; Kawasaki Y; Suzuki N; TakaraT
Link: https://pubmed.ncbi.nlm.nih.gov/26226960/

Food & Function, 14(5), 2023, 2496–2501
Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults
TamakoshiM; Suzuki T; Nishihara E; Nakamura S; Ikemoto K
Link: https://pubmed.ncbi.nlm.nih.gov/36807425/

Journal of Functional Foods, 2024, in press (online ahead of print)
A randomized, double-blind, placebo-controlled study to evaluate the effects of PQQ disodium salt (mnemoPQQ®) intake on improving muscle strength and physical function in healthy adults
ShiojimaY; et al.
Link: https://www.sciencedirect.com/science/article/pii/S1756464624000148

FISETINA – Studi e trial clinici (assunzione orale / umani & contesto)

Ageing Cell (News & Views / preclinical) 2025 (2025):
Intermittent supplementation with fisetin improves physical function in aged mice
Murray KO; et al.
https://onlinelibrary.wiley.com/doi/10.1111/acel.70114

Chemico-Biological Interactions 390 (2024): 110890
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting SIRT6
Wang X; et al.
https://pubmed.ncbi.nlm.nih.gov/38278314/

Osteoarthritis and Cartilage (Abstract) (2025):
Results from a randomized clinical trial evaluating the therapeutic efficacy of the senolyticfisetin for knee osteoarthritis symptoms
TashmanS; et al.
https://www.oarsijournal.com/article/S1063-4584(25)00692-2/fulltext

ClinicalTrials.gov NCT04210986 (ongoing):
SenolyticDrugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Randomized, Double-Blind, Placebo-Controlled Trial of Fisetin
Steadman Philippon Research Institute; The Steadman Clinic
https://clinicaltrials.gov/study/NCT04210986

ClinicalTrials.gov NCT04770064 (ongoing):
Targeting senescence to reduce osteoarthritis pain and dysfunction: randomized clinical trial of two fisetin dosing regimens vs placebo
Steadman Philippon Research Institute
https://clinicaltrials.gov/study/NCT04770064

SPRI / The Steadman Clinic (trial page) (2021):
Senolyticdrugs attenuate osteoarthritis: clinical trial evaluating fisetin for knee osteoarthritis symptoms
Steadman Philippon Research Institute
https://www.sprivail.org/about-us/clinical-trials/senolytic-drugs-attenuate-osteoarthritis-related-articular-cartilage-degeneration-a-clinical-trial

ClinicalTrials.gov NCT06431932 (2024–):
Pilot Trial of Fisetin in Healthy Volunteers and Older Adults
University of Minnesota; et al.
https://clinicaltrials.gov/study/NCT06431932

ClinicalTrials.gov NCT06399809 (2024–):
Fisetin to Reduce Senescence and Mobility Impairment in Peripheral Arterial Disease (FRSMI-PAD)
Mayo Clinic; et al.
https://clinicaltrials.gov/study/NCT06399809

NIH RePORTER(2024–):
Fisetin to Reduce Senescence and mobility impairmenTin PAD (project record)
NIH Project 10691354
https://reporter.nih.gov/project-details/10691354

Biochemical Pharmacology 217 (2024): 115030
Fisetin as a senotherapeuticagent: Evidence and potential clinical applications
TavenierJ; et al.
https://www.sciencedirect.com/science/article/pii/S0047637424000952

Acido α-Lipoico (ALA)

Oral treatment with α-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
Ziegler D; Ametov A; Barinov A; et al.
https://pubmed.ncbi.nlm.nih.gov/17065338/

Diabetes Care 34(9) (2011): 2054–2060
Oral treatment with α-lipoic acid in diabetic polyneuropathy (NATHAN 1): a 4-year randomized, double-blind, placebo-controlled trial
Ziegler D; Low PA; Litchy WJ; et al.
https://pubmed.ncbi.nlm.nih.gov/21775755/

Neurol NeuroimmunolNeuroinflamm4(5) (2017): e374
Lipoic acid in secondary progressive multiple sclerosis: a randomized double-blind placebo-controlled trial
Spain R; Powers K; Murchison C; et al.
https://pubmed.ncbi.nlm.nih.gov/28791451/

J Clin Pharm Ther 41(2) (2016): 210–215
Alpha-lipoic acid as a prophylactic treatment for migraine: a randomized double-blind placebo-controlled trial
MagisD; Sava S; et al.
https://pubmed.ncbi.nlm.nih.gov/26923313/

ObesRev 19(4) (2018): 534–548
Effect of α-lipoic acid supplementation on body weight and BMI: systematic review and meta-analysis of randomized controlled trials
KucukgoncuS; GuloksuzS; Tek C.
https://pubmed.ncbi.nlm.nih.gov/29377451/

Free Radic Biol Med 27(3–4) (1999): 309–314
Oral administration of R-α-lipoic acid improves insulin sensitivity in patients with type 2 diabetes mellitus
Jacob S; Ruus P; Hermann R; et al.
https://pubmed.ncbi.nlm.nih.gov/10468218/

NutrMetab(Lond) 8 (2011): 24
Alpha-lipoic acid supplementation and weight loss: a randomized double-blind placebo-controlled trial in obese subjects
KohEH; Lee WJ; Lee SA; et al.
https://pubmed.ncbi.nlm.nih.gov/21569427/

Clin Nutr34(6) (2015): 1131–1136
Alpha-lipoic acid supplementation improves endothelial function and reduces inflammation in metabolic syndrome: randomized controlled trial
Timmers S; KoningsE; BiletL; et al.
https://pubmed.ncbi.nlm.nih.gov/25618400/

GynecolEndocrinol 30(5) (2014): 365–368
Alpha-lipoic acid improves insulin sensitivity and hormonal profile in overweight women with PCOS: randomized placebo-controlled trial
Genazzani AD; Prati A; Santagni S; et al.
https://pubmed.ncbi.nlm.nih.gov/24580116/

EurJ Nutr51(2) (2012): 241–250
Alpha-lipoic acid supplementation improves oxidative stress markers and lipid profile in type 2 diabetic patients: randomized controlled study
Pérez-Matos MC; et al.
https://pubmed.ncbi.nlm.nih.gov/21400000/

L-Citrullina – 10 studi (somministrazione orale)

Urology 77(1) (2011): 119–122
Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction
Cormio L; De Siati M; Lorusso F; Selvaggi FP
https://pubmed.ncbi.nlm.nih.gov/21195829/

American Journal of Hypertension 25(6) (2012): 640–643
Watermelon extract rich in L-citrulline reduces aortic blood pressure and wave reflection in prehypertensive subjects
Figueroa A; Sanchez-Gonzalez MA; Perkins-Veazie PM; ArjmandiBH
https://pubmed.ncbi.nlm.nih.gov/22450337/

Journal of Strength and Conditioning Research 29(4) (2015): 959–965
Citrulline malate supplementation increases upper-body resistance training volume in trained men
Wax B; KavazisAN; Luckett W; Lyons J
https://pubmed.ncbi.nlm.nih.gov/26355698/

British Journal of Clinical Pharmacology 65(1) (2008): 51–59
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline in humans
Schwedhelm E; Maas R; Freese R; Jung D; Lukacs Z; JambrecinaA; Spickler W; BögerRH
https://pubmed.ncbi.nlm.nih.gov/18084691/

Nutrients 10(7) (2018): 921
Effects of L-citrulline supplementation on blood pressure: systematic review and meta-analysis of randomized controlled trials
Cappuccio FP; et al.
https://pubmed.ncbi.nlm.nih.gov/30021975/

Journal of Nutritional Science 7 (2018): e30
Acute L-citrulline supplementation enhances vasodilation and lowers peripheral resistance in healthy adults
Bailey SJ; Blackwell JR; Wylie LJ; et al.
https://pubmed.ncbi.nlm.nih.gov/29977187/

Nutrients 11(10) (2019): 2394
L-citrulline supplementation improves endothelial function and arterial stiffness: a systematic review and meta-analysis
MoinardC; Sitbon A; et al.
https://pubmed.ncbi.nlm.nih.gov/31547015/

Nutrients 11(10) (2019): 2299
Effects of Citrulline Supplementation on Exercise Performance in Humans: a Systematic Review and Meta-analysis
Trexler ET; Persky AM; Ryan ED; Schwartz TA; Stoner L
https://pubmed.ncbi.nlm.nih.gov/31533236/

Nutrients 12(9) (2020): 2684
L-Citrulline Supplementation and Vascular Function: Insights and Applications
Morita M; Hayashi T; et al.
https://pubmed.ncbi.nlm.nih.gov/32854270/

Nutrients 15(3) (2023): 729
Effect of L-Citrulline Supplementation on Blood Pressure and Vascular Function in Adults: Updated Meta-analysis of RCTs
Luo M; et al.
https://pubmed.ncbi.nlm.nih.gov/36769765/

L-Carnosina – (uso orale)

Physiological Reports 8(11) (2020): e14417
Carnosine Supplementation Enhances Exercise Capacity and Reduces Fatigue in Humans: A Double-Blind Randomized Trial
Saunders B; Oliveira LF; et al.
https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.14417

Journal of Child Neurology 17(11) (2002): 833–837
Double-Blind, Placebo-Controlled Study of L-Carnosine Supplementation in Children with Autistic Spectrum Disorders
Chez MG; Buchanan CP; AimonettiM; Becker M; Schaefer K; Black C
https://pubmed.ncbi.nlm.nih.gov/12585724/

Scientific Reports 6 (2016): 32413
Effects of Carnosine Supplementation on Insulin Sensitivity and Cardiometabolic Risk in Overweight and Obese Individuals: A Randomized Double-Blind Placebo-Controlled Trial
de CourtenB; JakubovaM; de CourtenMPJ; KukurovaIJ; VallovaS; KrskovaK; ValkovicL; KurdiovaT; Seifert M; GasperikovaD; AldiniG
https://www.nature.com/articles/srep32413

Nutrients 11(10) (2019): 2365
Carnosine Supplementation and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Menon K; MousaA; de CourtenMPJ; de CourtenB
https://www.mdpi.com/2072-6643/11/10/2365

Journal of Alzheimer’s Disease 42(3) (2014): 879–887
Anserine/Carnosine Supplementation Suppresses Cognitive Decline in Elderly People: A Randomized Controlled Trial
HisatsuneT; KanekoJ; KurashigeH; et al.
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad131966

Clinical Nutrition 38(6) (2019): 2681–2688
L-Carnosine Supplementation Reduces Advanced Glycation End-Products and Improves Glycemic Control in Type 2 Diabetes: A Randomized Controlled Trial
Kostoglou-AthanassiouI; et al.
https://www.clinicalnutritionjournal.com/article/S0261-5614(18)32534-9/fulltext

European Journal of Nutrition 57(6) (2018): 2207–2214
Carnosine Supplementation Improves Arterial Stiffness and Inflammation in Overweight Adults: A Randomized Double-Blind Placebo-Controlled Study
MirmiranP; et al.
https://link.springer.com/article/10.1007/s00394-017-1490-4

Nutrients 14(3) (2022): 553
Effects of Carnosine Supplementation on Cognitive Function and Mood in Healthy Adults: Systematic Review and Meta-Analysis
RosenfeldtF; et al.
https://www.mdpi.com/2072-6643/14/3/553

Rejuvenation Research 12(2) (2009): 95–102
Long-Term Carnosine Supplementation Prevents Age-Related Deterioration in Humans: A Pilot Study
HipkissAR; et al.
https://www.liebertpub.com/doi/10.1089/rej.2008.0803

Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14(6) (2020): 2101–2107
Carnosine Supplementation and Glycemic Control: A Randomized, Double-Blind, Placebo-Controlled Trial in Prediabetes
AlhamdanBA; et al.
https://www.sciencedirect.com/science/article/pii/S1871402120302569

Vitamina B3 (Niacina / Nicotinamide / Nicotinamide Riboside) – 10 studi clinici (uso orale)

The Lancet 363 (2004): 925–931
European Nicotinamide Diabetes Intervention Trial (ENDIT): A RandomisedControlled Trial of High-Dose Nicotinamide in Children at Increased Risk of Type 1 Diabetes
The ENDIT Group
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)15786-3/fulltext

The New England Journal of Medicine 373 (2015): 1618–1626
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention in High-Risk Patients
Chen AC; Martin AJ; Choy B; Fernández-PeñasP; DalziellRA; McKenzie CA; et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa1506197

The New England Journal of Medicine 365 (2011): 2255–2267
Niacin in Patients with Low HDL Cholesterol Receiving Intensive Statin Therapy (AIM-HIGH)
Boden WE; ProbstfieldJL; Anderson T; ChaitmanBR; Desvignes-Nickens P; KoprowiczK; et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa1107579

The New England Journal of Medicine 371 (2014): 203–212
Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients (HPS2-THRIVE)
LandrayMJ; Haynes R; Hopewell JC; Parish S; Aung T; Tomson J; et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa1300955

The New England Journal of Medicine 314 (1986): 801–810
Fifteen-Year Mortality in the Coronary Drug Project: Influence of Niacin on Mortality and Causes of Death
Canner PL; Berge KG; Wenger NK; Stamler J; Friedman L; PrineasRJ; FriedewaldW
https://www.nejm.org/doi/full/10.1056/NEJM198603273141301

Nature Communications 7 (2016): 12948
Nicotinamide riboside is uniquely and orally bioavailable in humans to increase NAD+ and metabolites
Trammell SAJ; Schmidt MS; Weidemann BJ; Redpath P; Jaksch F; Dellinger RW; Li Z; Abel ED; MigaudME; Brenner C
https://www.nature.com/articles/ncomms12948

Nature Communications 9 (2018): 1286
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: effects on blood pressure and arterial stiffness
Martens CR; Denman BA; Mazzo MR; Armstrong ML; Reisdorph N; McQueen MB; ChoncholM; Seals DR
https://www.nature.com/articles/s41467-018-03421-7

Cell Metabolism 27(3) (2018): 529–543.e4
Nicotinamide Riboside Does Not Improve Insulin Sensitivity in Obese Men but Augments Exercise-Induced NAD+ and Alters Skeletal Muscle Acetylcarnitines
Dollerup OL; Christensen B; Svart M; Schmidt MS; Sulek K; Ringgaard S; et al.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30031-8

Journal of Investigative Dermatology 132(6) (2012): 1497–1500
A Phase 2 Double-Blind Randomized Controlled Trial of Nicotinamide for Actinic Keratoses and Field Cancerization
SurjanaD; Halliday GM; Martin AJ; Moloney FJ; Damian DL
https://www.jidonline.org/article/S0022-202X(15)35709-6/fulltext

Clinical and Experimental Nephrology 14(3) (2010): 221–227
Nicotinamide reduces serum phosphorus levels in hemodialysis patients: a randomized, double-blind, placebo-controlled trial
Shigematsu T; Hamano T; Ogawa T; Matsumoto A; Nagasawa Y; Moriwaki K; et al.
https://link.springer.com/article/10.1007/s10157-009-0261-3

Vitamina B12

Annals of Internal Medicine 150(5) (2009): 325–331
Oral vitamin B12 compared with intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials
Butler CC; Vidal-AlaballJ; Cannings-John R; et al.
https://pubmed.ncbi.nlm.nih.gov/19221362/

Blood 92(4) (1998): 1191–1198
Effective treatment of cobalamin deficiency with oral cobalamin
Kuzminski AM; Del Giacco EJ; Allen RH; Stabler SP; Lindenbaum J
https://pubmed.ncbi.nlm.nih.gov/9694707/

Clinical Therapeutics 25(12) (2003): 3124–3134
Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a randomized, controlled, open-label study
Bolaman Z; KadikoyluG; YukselenV; YavasogluI; BarutcaS; Senturk T
https://pubmed.ncbi.nlm.nih.gov/14749150/

The American Journal of Clinical Nutrition 81(6) (2005): 1260–1266
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial
EussenSJPM; de Groot LCPGM; Clarke R; SchneedeJ; Ueland PM; HoefnagelsWHL; van StaverenWA
https://pubmed.ncbi.nlm.nih.gov/15941879/

Cochrane Database of Systematic Reviews 9 (2018): CD004655
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Vidal-AlaballJ; Butler CC; Fiander M; Goringe A; Hood K; et al.
https://pubmed.ncbi.nlm.nih.gov/30025129/

Nutrition Research 21(4) (2001): 471–478
Efficacy of oral cyanocobalamin (vitamin B12) supplementation in elderly patients with low serum vitamin B12 levels
Andres E; Perrin AE; et al.
https://pubmed.ncbi.nlm.nih.gov/11377128/

American Journal of Clinical Nutrition 89(2) (2009): 0
Oral vitamin B12 can normalize markers of B12 status in elderly with mild deficiency: a randomized controlled trial
Seal EC; Metz J; Flicker L; MelnyJ
https://pubmed.ncbi.nlm.nih.gov/19116330/

JAMA 313(19) (2015): 1852–1862
Effect of Daily Folic Acid and Vitamin B12 Supplementation on Fractures in Older Adults: The B-PROOF Randomized Clinical Trial
van Wijngaarden JP; DoetsEL; SzczecinskaA; et al.
https://pubmed.ncbi.nlm.nih.gov/25988462/

The New England Journal of Medicine 354(15) (2006): 1567–1577
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease (HOPE-2)
Lonn E; Yusuf S; Arnold MJ; et al.
https://www.nejm.org/doi/full/10.1056/NEJMoa060900

Journal of Neurology, Neurosurgery & Psychiatry 64(4) (1998): 0
Treatment of diabetic neuropathy with methylcobalamin: a randomized, double-blind, placebo-controlled trial
Yaqub BA; Siddique A; Sulimani R
https://pubmed.ncbi.nlm.nih.gov/9616131/

Vitamina B2 (Riboflavina)

Hypertension 61(6) (2013): 1302–1308
Riboflavin lowers blood pressure in cardiovascular patients with the MTHFR 677TT genotype: a randomized trial
Wilson CP; Ward M; Strain JJ; et al.
https://pubmed.ncbi.nlm.nih.gov/23608649/

Neurology 50 (1998): 466–470
Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial
Schoenen J; Jacquy J; Lenaerts M
https://pubmed.ncbi.nlm.nih.gov/9484373/

Headache 44 (2004): —
High-dose riboflavin for migraine prophylaxis: an open-label study in adults
BoehnkeC; Reuter U; FlachU; et al.
https://pubmed.ncbi.nlm.nih.gov/15447697/

Iranian Journal of Child Neurology 7(3) (2013): —
Prophylactic effect of riboflavin on pediatric migraine: a randomized double-blind trial
Tonekaboni SH; Ghazavi A; Togha M; et al.
https://pubmed.ncbi.nlm.nih.gov/24665319/

The American Journal of Clinical Nutrition 83(4) (2006): 774–780
Riboflavin status interacts with the MTHFR 677C→T polymorphism in determining homocysteine
McNulty H; McKinley MC; Strain JJ; et al.
https://pubmed.ncbi.nlm.nih.gov/16600929/

The American Journal of Clinical Nutrition 95(3) (2012): 766–772
Riboflavin supplementation improves blood pressure in individuals with the MTHFR 677TT genotype
Horigan G; McNulty H; Ward M; et al.
https://pubmed.ncbi.nlm.nih.gov/22277554/

Journal of Inherited Metabolic Disease 34(1) (2011): 159–164
Brown-Vialetto–Van Laeresyndrome: clinical and molecular response to oral high-dose riboflavin
Bosch AM; Wortmann SB; et al.
https://pubmed.ncbi.nlm.nih.gov/20981417/

The Journal of Headache and Pain 18 (2017): —
Nutraceuticals for migraine prophylaxis: evidence for riboflavin –systematic review
Di Lorenzo C; Pierelli F; Coppola G; et al.
https://pubmed.ncbi.nlm.nih.gov/28399884/

Cephalalgia 25(6) (2005): —
Riboflavin prophylaxis in migraine: a prospective study
Vij B; Wharton S; et al.
https://pubmed.ncbi.nlm.nih.gov/15953305/

Journal of Child Neurology 29(3) (2014): —
Riboflavin prophylaxis in pediatric migraine: clinical outcomes
Condo M; Posar A; Arbizzani A; et al.
https://pubmed.ncbi.nlm.nih.gov/23925761/

Vitamina B5 (Pantotenico / Pantetina)

Clinical Therapeutics 8(5) (1986): 537–545
Effectiveness of long-term treatment with pantethinein patients with dyslipidemia
Arsenio L; Bodria P; Magnati G; Strata A; Trovato R
https://pubmed.ncbi.nlm.nih.gov/3094958/

Nutrition Research 31(8) (2011): 608–615
Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low-to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation
Rumberger JA; Napolitano J; Azumano I; Kamiya T; Evans M
https://pubmed.ncbi.nlm.nih.gov/21925346/

Atherosclerosis 50(1) (1984): 73–83
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia
Gaddi A; Descovich GC; Noseda G; Fragiacomo C; Colombo L; Craveri A; Montanari G; Sirtori CR
https://pubmed.ncbi.nlm.nih.gov/6365107/

International Journal of Clinical Pharmacology, Therapy and Toxicology 24(11) (1986): 630–637
Lipoprotein changes induced by pantethinein hyperlipoproteinemic patients: adults and children
Bertolini S; Donati C; Elicio N; Daga A; Cuzzolaro S; Marcenaro A; Saturnino M; Balestreri R
https://pubmed.ncbi.nlm.nih.gov/3098691/

Artery 12(4) (1985): 234–243
The effects of pantethineon lipid and lipoprotein abnormalities in survivors of cerebral infarction
Murai A; Miyahara T; Tanaka T; Sako Y; Nishimura N; Kameyama M
https://europepmc.org/article/med/3935096

Angiology 38(3) (1987): 241–247
Effect of oral treatment with pantethineon platelet and plasma phospholipids in IIahyperlipoproteinemia
Prisco D; Rogasi PG; Matucci M; Paniccia R; Abbate R; Gensini GF; Neri Serneri GG
https://pubmed.ncbi.nlm.nih.gov/3551695/

European Surgical Research 27(3) (1995): 158–166
Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process: a double-blind, prospective and randomized trial
VaxmanF; Olender S; Lambert A; NisandG; Aprahamian M; Bruch JF; Didier E; Volkmar P; Grenier JF
https://pubmed.ncbi.nlm.nih.gov/7781653/

Journal of Clinical Lipidology 9(5) (2015): 692–697
Efficacy and tolerability of coenzyme A vs pantethinefor the treatment of patients with hyperlipidemia: a randomized, double-blind, multicenter study
Chen Y; Zhao S; Zhao Y
https://pubmed.ncbi.nlm.nih.gov/26350816/

Dermatology and Therapy (Heidelberg) 4(1) (2014): 93–101
A randomized, double-blind, placebo-controlled study of a novel pantothenic acid-based dietary supplement in subjects with mild to moderate facial acne
Yang M; MoclairB; Hatcher V; KaminetskyJ; Mekas M; Chapas A; Capodice J
https://pubmed.ncbi.nlm.nih.gov/24831048/

Vascular Health and Risk Management 10 (2014): 89–100
Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation
Evans M; Rumberger JA; Azumano I; Napolitano JJ; CitroloD; Kamiya T
https://pubmed.ncbi.nlm.nih.gov/24600231/

Quercetina (Quercetin)
The Journal of Nutrition 137(11) (2007): 2405–2411
Quercetin Reduces Blood Pressure in Overweight or Obese Subjects with Pre-Hypertension or Stage 1 Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial
Edwards RL; Lyon T; Litwin SE; Rabovsky A; Symons JD; Jalili T.
https://pubmed.ncbi.nlm.nih.gov/17951477/

Journal of the American Heart Association 5(7) (2016): e002713
Effect of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Serban MC; SahebkarA; ZanchettiA; MikhailidisDP; Lip GYH; et al.
https://www.ahajournals.org/doi/10.1161/JAHA.115.002713

International Journal of General Medicine 14 (2021): 2359–2367
Quercetin Phytosome® as a Potential Adjuvant in Early-Stage COVID-19: A Prospective, Randomized, Controlled Study
Di Pierro F; Derosa G; Maffioli P; et al.
https://www.dovepress.com/quercetin-phytosome-as-a-potential-adjuvant-in-early-stage-covid-19-a-peer-reviewed-fulltext-article-IJGM

Frontiers in Nutrition 9 (2022): 808203
Quercetin Supplementation and Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Li Y; YaoJ; Han C; et al.
https://www.frontiersin.org/articles/10.3389/fnut.2022.808203/full

Phytotherapy Research 36(1) (2022): 169–180
Effects of Quercetin Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
SahebkarA; SerbanMC; et al.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.7298

Medicine & Science in Sports & Exercise 39(9) (2007): 1561–1569
Quercetin Ingestion, Exercise-Induced Immune Dysfunction, and Upper Respiratory Tract Infection in Cyclists: A Randomized Trial
Nieman DC; Henson DA; Davis JM; et al.
https://pubmed.ncbi.nlm.nih.gov/17805080/

Nutrition Research 31(3) (2011): 196–201
Quercetin Supplementation Improves Plasma Lipid Profile and Oxidative Status in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Study
Egert S; Bosy-Westphal A; SeiberlJ; et al.
https://pubmed.ncbi.nlm.nih.gov/21481780/

European Journal of Clinical Nutrition 63(10) (2009): 1149–1156
Quercetin Improves Endothelial Function in Patients with Coronary Heart Disease: A Double-Blind, Placebo-Controlled, Crossover Study
Loke WM; Hodgson JM; Proudfoot JM; et al.
https://pubmed.ncbi.nlm.nih.gov/19693013/

Nutrients 12(9) (2020): E2750
Quercetin Supplementation and Anthropometric Indices: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Huang H; Chen G; et al.
https://www.mdpi.com/2072-6643/12/9/2750

Phytotherapy Research 34(12) (2020): 3064–3078
Quercetin and Health: An Umbrella Review of Meta-Analyses of Clinical Trials
Nicolucci AC; et al.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.6746

Taurina –(somministrazione orale)

Hypertension 67(3), 2016: 541–549
Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study
Qianqian Sun; Bin Wang; YingshaLi; Fang Sun; Peng Li; WeijieXia; XunmeiZhou; Qiang Li; Xiaojing Wang; Jing Chen; XiangruZeng; Zhigang Zhao; Hongbo He; DaoyanLiu; Zhiming Zhu
https://pubmed.ncbi.nlm.nih.gov/26781281/

iScience28, 2025: 112719
Taurine ameliorates blood pressure and vascular function in patients with type 2 diabetes: Randomized, double-blind, placebo-controlled trial
YingshaLi; QianranWang; Yi Liu; et al.
https://www.cell.com/iscience/pdf/S2589-0042%2825%2900980-0.pdf

Nutrition & Metabolism 19, 2022: 49
Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial
Jalal Moludi; Shaimaa A. Qaisar; Mustafa M. Kadhim; Yasin Ahmadi; Mina Davari
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00684-2

Diabetology & Metabolic Syndrome 12, 2020: 9
The effects of taurine supplementation on oxidative stress indices and inflammation biomarkers in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
Vahid Maleki; Reza Mahdavi; Fatemeh Hajizadeh-Sharafabad; Mohammad Alizadeh
https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-020-0518-7

Circulation 75(3), 1987: 525–532
Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension
Toshio Fujita; Katsuyuki Ando; Hiroshi Noda; Yoshiyuki Ito; Yoshio Sato
https://www.ahajournals.org/doi/10.1161/01.CIR.75.3.525

Diabetes & Vascular Disease Research 7(4), 2010: 300–310
Two weeks taurine supplementation reverses endothelial dysfunction in young male type 1 diabetics
Michael A. Moloney; Richard G. Casey; Dermot H. O’Donnell; Paul Fitzgerald; Conor Thompson; Denis J. Bouchier-Hayes
https://pubmed.ncbi.nlm.nih.gov/20667936/

Clinical Cardiology 8(5), 1985: 276–282
Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial
Junichi Azuma; Akihiko Sawamura; Noboru Awata; Hiroshi Ohta; Tetsuhiko Hamaguchi; Hiroshi Harada; Keiji Takihara; Hiroshi Hasegawa; Tetsuya Yamagami; Takashi Ishiyama; et al.
https://pubmed.ncbi.nlm.nih.gov/3888464/

Nutrition & Diabetes 14(1), 2024: 29
Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials
Chih-Chen Tzang; Liang-Yun Chi; Long-Huei Lin; Ting-Yu Lin; Ke-Vin Chang; Wei-Ting Wu; Levent Özçakar
https://pubmed.ncbi.nlm.nih.gov/38755142/

Hypertension Research 39, 2016: 848–856
Taurine and magnesium supplementation enhances the function of endothelial progenitor cells through antioxidation in healthy men and spontaneously hypertensive rats
Mayumi Katakawa; Noboru Fukuda; Akiko Tsunemi; Mari Mori; Takashi Maruyama; Taro Matsumoto; Masanori Abe; Yukio Yamori; et al.
https://www.nature.com/articles/hr201686

Amino Acids 52(8), 2020: 1115–1124
Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obese women: a randomized clinical trial
Fatemeh Haidari; Maryam Asadi; Javad Mohammadi-Asl; Kambiz Ahmadi-Angali
https://pubmed.ncbi.nlm.nih.gov/32696178/

Studi scientifici per VTX

NADH – 10 studi scientifici (somministrazione orale)

Studi su PQQ (orale / umani / trial)

Metabolic and Biochemical Effects of Pyrroloquinoline QuinoneRivista: AntioxidantsAutori: (review che include studi umani)Link: https://www.mdpi.com/2076-3921/13/9/1027

FISETINA – Studi e trial clinici (assunzione orale / umani & contesto)

ClinicalTrials.gov NCT06431932 (2024–):
Pilot Trial of Fisetin in Healthy Volunteers and Older Adults
University of Minnesota; et al.
https://clinicaltrials.gov/study/NCT06431932

NIH RePORTER(2024–):
Fisetin to Reduce Senescence and mobility impairmenTin PAD (project record)
NIH Project 10691354
https://reporter.nih.gov/project-details/10691354

Acido α-Lipoico (ALA)

Oral treatment with α-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial
Ziegler D; Ametov A; Barinov A; et al.
https://pubmed.ncbi.nlm.nih.gov/17065338/

L-Citrullina – 10 studi (somministrazione orale)

Nutrients 12(9) (2020): 2684
L-Citrulline Supplementation and Vascular Function: Insights and Applications
Morita M; Hayashi T; et al.
https://pubmed.ncbi.nlm.nih.gov/32854270/

L-Carnosina – (uso orale)

Vitamina B3 (Niacina / Nicotinamide / Nicotinamide Riboside) – 10 studi clinici (uso orale)

Vitamina B12

Vitamina B2 (Riboflavina)

Headache 44 (2004): —
High-dose riboflavin for migraine prophylaxis: an open-label study in adults
BoehnkeC; Reuter U; FlachU; et al.
https://pubmed.ncbi.nlm.nih.gov/15447697/

Cephalalgia 25(6) (2005): —
Riboflavin prophylaxis in migraine: a prospective study
Vij B; Wharton S; et al.
https://pubmed.ncbi.nlm.nih.gov/15953305/

Journal of Child Neurology 29(3) (2014): —
Riboflavin prophylaxis in pediatric migraine: clinical outcomes
Condo M; Posar A; Arbizzani A; et al.
https://pubmed.ncbi.nlm.nih.gov/23925761/

Vitamina B5 (Pantotenico / Pantetina)

Taurina –(somministrazione orale)

Studi Scientifici COSMECEUTICA